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Physiological features of visceral smooth muscle cells, with special reference to receptors and ion channels.
The features of ion channels in vascular tissues only recently are reviewed, since this article makes only limited reference to vascular smooth muscle research.
Membrane hyperpolarization inhibits agonist‐induced synthesis of inositol 1,4,5‐trisphosphate in rabbit mesenteric artery.
- T. Itoh, N. Seki, S. Suzuki, S. Ito, J. Kajikuri, H. Kuriyama
- Biology, ChemistryJapanese journal of pharmacology
- 1 June 1992
It is suggested that membrane hyperpolarization is essential for the inhibitory action of pinacidil on the NA‐induced Ca2(+)‐releasing mechanism through an inhibition of IP3 synthesis resulting from its membranehyperpolarizing action.
Motion compensation for ISAR via centroid tracking
A compensation method of target radial motion is formulated and applied to obtain focused images in inverse synthetic aperture radar (ISAR). The basic scheme is to estimate the radial motion of the…
Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells
Results provide a direct demonstration at the level of a single cell that activation of the calmodulin–MLCK pathway is both necessary and sufficient to trigger contraction of smooth muscle.
Effects of protamine on vascular smooth muscle of rabbit mesenteric artery.
It is concluded that protamine exerts its inhibition on vascular smooth muscles in both an endothelium-dependent and -independent manner, and direct smooth muscle effects are due to the inhibition of both Ca(2+)-influx and the NE-induced Ca2+ release from intracellular stores.
Overexpression of myosin phosphatase reduces Ca(2+) sensitivity of contraction and impairs cardiac function.
- H. Mizutani, R. Okamoto, Masaaki Ito
- Biology, MedicineCirculation journal : official journal of the…
Overexpression of MYPT2 and the increase in PP1cdelta resulted in an increase of the MP holoenzyme and a decrease in the level of MLC phosphorylation, which proves that myosin phosphatase target subunit 2 is truly the regulatory subunit of cardiac MP in-vivo and plays a significant role in modulating cardiac function.
Characteristic features of noradrenaline‐induced Ca2+ mobilization and tension in arterial smooth muscle of the rabbit.
The results suggest that NAd increases the sensitivity of contractile proteins to Ca2+ in smooth muscle of the rabbit mesenteric artery through releases from the ryanodine‐sensitive Ca 2+ storage sites.
Membrane hyperpolarization inhibits agonist-induced synthesis of inositol 1,4,5-trisphosphate in rabbit mesenteric artery.
Differences and similarities in the noradrenaline‐ and caffeine‐induced mechanical responses in the rabbit mesenteric artery
1. The properties of noradrenaline (NA)‐induced and caffeine‐induced contractions in the rabbit mesenteric artery were investigated and compared, using intact and skinned muscles.
A phorbol ester has dual actions on the mechanical response in the rabbit mesenteric and porcine coronary arteries.
TPA shows dual actions on the contractile machinery and may act on the regulatory systems of contractile proteins and the physiological action of protein kinase C as estimated from the action of TPA seems to be related to an excitatory action on thecontractile machinery.