Pro-Opiomelanocortin

Known as: Endorphin-ACTH Precursor, pro-opiomelanocortin (POMC), Pro-ACTH-Endorphin 
A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral… (More)

Topic mentions per year

Topic mentions per year

1978-2018
05010019782018

Papers overview

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Highly Cited
2010
Highly Cited
2010
Circulating leptin and insulin convey information regarding energy stores to the central nervous system, particularly the… (More)
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Highly Cited
2008
Highly Cited
2008
Drugs activating 5-hydroxytryptamine 2C receptors (5-HT2CRs) potently suppress appetite, but the underlying mechanisms for these… (More)
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Highly Cited
2006
Highly Cited
2006
The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that regulates cell-cycle progression and growth by… (More)
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Highly Cited
2004
Highly Cited
2004
Inactivating mutations of the pro-opiomelanocortin (POMC) gene in both mice and humans leads to hyperphagia and obesity. To… (More)
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Highly Cited
2002
Highly Cited
2002
Food intake is regulated by the hypothalamus, including the melanocortin and neuropeptide Y (NPY) systems in the arcuate nucleus… (More)
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Highly Cited
2001
Highly Cited
2001
The administration of leptin to leptin-deficient humans, and the analogous Lepob/Lepob mice, effectively reduces hyperphagia and… (More)
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Highly Cited
1998
Highly Cited
1998
Reduction in the activity of the alpha-melanocyte-stimulating hormone (alpha-MSH) system causes obesity, and infusions of alpha… (More)
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Highly Cited
1997
Highly Cited
1997
Melanocortins are peptides, cleaved from the pro-opiomelanocortin (POMC) precursor, that act in the brain to reduce food intake… (More)
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Highly Cited
1996
Highly Cited
1996
The pituitary gland contains six distinct hormone-producing cell types that arise sequentially during organogenesis. The first… (More)
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Highly Cited
1994
Highly Cited
1994
POMC, the precursor of ACTH, MSH, and beta-endorphin peptides, is expressed in the pituitary and in two sites in the brain, in… (More)
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