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Pro-Opiomelanocortin

Known as: Endorphin-ACTH Precursor, pro-opiomelanocortin (POMC), Pro-ACTH-Endorphin 
A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral… 
National Institutes of Health

Related topics

Related topics

23 relations
CorticotropinEndorphinsIn BloodMelanocyte stimulating hormone

Narrower (7)

MSH, Lys-gamma(2)MSH, Lys-gamma(3)OpiocortinPreproopiomelanocortin

Broader (2)

Pituitary HormonesProtein Precursors

Papers overview

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Highly Cited
2003
Highly Cited
2003
Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats.
Zucker (fa/fa) rats with defective leptin receptors are obese, hyperphagic, and hyperinsulinemic. For testing whether chronic… 
Highly Cited
1999
Highly Cited
1999
Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal…
We recently characterized leukemia inhibitory factor (LIF) as an important modulator of hypothalamo-pituitary-adrenal (HPA) axis… 
Review
1996
Review
1996
Proopiomelanocortin, its derived peptides, and the skin.
Proopiomelanocortin (POMC) is a protein synthesized predominately in the pituitary gland but also in a variety of other tissues… 
Highly Cited
1994
Highly Cited
1994
Fast glucocorticoid feedback inhibition of ACTH secretion in the ovariectomized rat: effect of chronic estrogen and progesterone.
The purpose of this study was to determine whether estrogen and progesterone influence fast glucocorticoid negative feedback… 
Highly Cited
1989
Highly Cited
1989
Testosterone regulation of proopiomelanocortin messenger ribonucleic acid in the arcuate nucleus of the male rat.
GnRH regulates the secretion of LH and FSH, which stimulate the secretion of testicular hormones. Acting in a reciprocal fashion… 
Highly Cited
1986
Highly Cited
1986
GABAergic regulation of melanocyte-stimulating hormone secretion from the pars intermedia of Xenopus laevis: immunocytochemical and physiological evidence.
alpha-MSH secretion from the amphibian pars intermedia is under inhibitory hypothalamic control, and the catecholamine dopamine… 
Highly Cited
1982
Highly Cited
1982
Characterization of pro-opiocortin-converting activity in purified secretory granules from rat pituitary neurointermediate lobe.
Lysates of secretory granules from rat pituitary neurointermediate lobes were incubated with [3H]arginine- or [3H]phenylalanine… 
Highly Cited
1980
Highly Cited
1980
Evidence for homologous actions of pro-opiocortin products.
alpha-Melanocyte-stimulating hormone (alpha-MSH), a modified fragment of adrenocorticotropic hormone, derives from the same… 
Highly Cited
1979
Highly Cited
1979
Adrenalectomy, dexamethasone or stress alters opioid peptides levels in rat anterior pituitary but not intermediate lobe or brain.
Highly Cited
1978
Highly Cited
1978
Characterization of pro-opiocortin, a precursor to opioid peptides and corticotropin.
The high molecular weight (approximately 30,000) precursor to opioid activity (pro-opiocortin) previously detected in extracts of… 
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