Opiocortin
National Institutes of Health
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The endogenous opioid peptides are derived from three large precursors. Pro-opiocortin and proenkephalin yield [Met]enkephalin…
Lysates of secretory granules from rat pituitary neurointermediate lobes were incubated with [3H]arginine- or [3H]phenylalanine…
Chromatography under acid dissociating conditions in conjunction with radioimmunoassay has been employed to investigate the…
alpha-Melanocyte-stimulating hormone (alpha-MSH), a modified fragment of adrenocorticotropic hormone, derives from the same…
Pro-opiocortin was purified from camel pituitaries by procedures including high-performance liquid chromatography. The precursor…
SummaryIn man, discrete neurons of the infundibular (arcuate) nucleus contain compounds that can be stained with anti-endorphin…
The high molecular weight (approximately 30,000) precursor to opioid activity (pro-opiocortin) previously detected in extracts of…