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Identification of two related pentapeptides from the brain with potent opiate agonist activity
- J. Hughes, T. Smith, H. Kosterlitz, L. Fothergill, B. Morgan, H. Morris
- Chemistry, BiologyNature
- 1 December 1975
The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl–Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.
Endogenous opioid peptides: multiple agonists and receptors
It is concluded that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor.
- H. Kosterlitz
Opiate Receptor Mechanisms: Neurochemical and Neurophysical Processes in Opiate Drug Action and Addiction.(Based on a work session of the Neurosciences Research Program.) By Solomon H. Snyder and…
Kinetic parameters of narcotic agonists and antagonists, with particular reference to N-allylnoroxymorphone (naloxone).
It seemed of interest, therefore, to examine the kinetics of these drugs and for this purpose the following parameters were chosen: the concentration causing 50% inhibition of the contraction of the longitudinal muscle (ID50), to characterize agonist activity; the equilibrium constant and the recovery rate constant, to characterize antagonist activity.
Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor
- A. Corbett, S. Paterson, A. McKnight, J. Magnan, H. Kosterlitz
- Biology, ChemistryNature
- 2 September 1982
It is generally accepted that there are three subtypes of opiate receptor: µ, δ and κ. The main endogenous ligands for the µ-and δ-sites are Met5-enkephalin, Leu5-enkephalin and β-endorphin, whereas…
Selectivity of ligands for opioid receptors
The endogenous opioid peptides are derived from three precursor molecules, proopiomelanocortin, proenkephalin, and prodynorphin, and interact with three well-defined types of receptor, μ, δ, and ĸ (see Paterson et al. 1984).
THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES
It is suggested that the enkephalins may have a neurotransmitter role in both brain and peripheral tissues and that methionine‐ and leucine‐enkephalin may subserve separate neuronal functions.
SPECTRUM OF THE μ‐, δ‐ AND κ‐BINDING SITES IN HOMOGENATES OF RAT BRAIN
The κ‐binding site had the lowest value whereas in the guinea‐pig brain the capacity of the μ‐ binding site was lower than that of the δ‐ or δ-binding site.
PHARMACOLOGICAL ANALYSIS OF INTRINSIC INTESTINAL REFLEXES.
A new example of a morphine‐sensitive neuro‐effector junction: Adrenergic transmission in the mouse vas deferens
It is concluded that adrenergic neurotransmission in the mouse vas deferens differs in some important way from that at the more common, morphine-insensitive, adrenergic junctions.