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The diagnosis and medical management of advanced neuroendocrine tumors.
TLDR
Assessment of specific or general tumor markers offers high sensitivity in establishing the diagnosis and can also have prognostic significance, and therapy with radionuclides may be used for tumors exhibiting uptake to a diagnostic scan, either after surgery to eradicate microscopic residual disease or later if conventional treatment or biotherapy fails. Expand
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome
TLDR
The findings suggest that HRPT2 is a tumor-suppressor gene, the inactivation of which is directly involved in predisposition to HPT–JT and in development of some sporadic parathyroid tumors. Expand
Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist
TLDR
Pegvisomant is an effective medical treatment for acromegaly and of the patients treated for 12 months or more, 87 of 90 (97%) achieved a normal serum IGF-1 concentration. Expand
The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up.
TLDR
A variety of tests and imaging studies are necessary for the correct diagnosis of the EAS, but up to 20% of cases present a covert or occult EAS syndrome, and these cases require a prolonged follow-up, review, and repetition of diagnostic tests and scans. Expand
Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant.
TLDR
Treatment of patients who have acromegaly with pegvisomant with a growth hormone-receptor antagonist results in a reduction in serum IGF-I concentrations and in clinical improvement. Expand
DIAGNOSIS AND MANAGEMENT OF ACTH‐DEPENDENT CUSHING'S SYNDROME: COMPARISON OF THE FEATURES IN ECTOPIC AND PITUITARY ACTH PRODUCTION
TLDR
All patients in whom the ectopic ACTH‐secreting tumour was obvious at presentation died of their primary tumour within 8 months, whereas seven of the 10 patients with occult tumours at presentation are alive 1·5–16·5 years later, and appear cured. Expand
Hypothalamo-pituitary abnormalities in adult patients with langerhans cell histiocytosis: clinical, endocrinological, and radiological features and response to treatment.
TLDR
In adult patients with hypothalamic LCH and DI, anterior pituitary hormonal deficiencies developed in 8 of 12 patients; these occurred over the course of 20 yr; these were frequently accompanied by structural changes of the HPA, although these were often subtle in nature. Expand
Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism.
TLDR
The single-stranded conformational polymorphism identification of CaR mutations may help in the distinction of FBH from mild primary hyperparathyroidism which can be clinically difficult. Expand
Characterization of mutations in patients with multiple endocrine neoplasia type 1.
TLDR
The results provide the basis for a molecular-genetic screening approach that will supplement the clinical evaluation and genetic counseling of members of MEN1 families and SSCP was found to be a sensitive and specific mutational screening method that detected >85% of the mutations. Expand
Failure to preserve fertility in patients with Hodgkin's disease
TLDR
In the dosages and schedules investigated, buserlin was ineffective in conserving fertility. Expand
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