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Early pregnancy termination with mifepristone and misoprostol in the United States.
TLDR
This mifepristone-misoprostol regimen is effective in terminating pregnancies, especially in women with pregnancies of 49 days' duration or less, and increased with advancing gestational age.
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Differential regulation of steroidogenic enzymes during differentiation optimizes testosterone production by adult rat Leydig cells.
TLDR
The progressive increase in the capacity of differentiating Leydig cells to produce testosterone can be explained in part by an increase inThe activity of enzymes that synthesize testosterone and P450-17 alpha and a decrease in the activity of an enzyme that metabolizes testosterone and its precursors (3 alpha HSD).
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Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis.
  • A. HsuehK. Dahl W. Vale
  • Biology, Medicine
    Proceedings of the National Academy of Sciences…
  • 1 July 1987
TLDR
Test data indicate that the inhibin-related gene products synthesized by Sertoli and granulosa cells may form heterodimer or homodimers to serve as intragonadal paracrine signals in the modulation of LH-stimulated androgen biosynthesis and allow cross-communication between the two feedback loops.
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Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms.
The demonstration that luteinizing hormone (LH) release from the pituitary is episodic rather than constant raises fundamental questions regarding the physiologic control of pulsatile LH secretion…
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Purification of gonadotropin surge-inhibiting factor from Sertoli cell-enriched culture medium.
TLDR
It is demonstrated that GnSIF is a unique protein that shares some biological activities with inhibin, a novel biological factor in follicular fluid that inhibits the pre-ovulatory LH and FSH surges.
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Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.
TLDR
There is a remarkable similarity between the amino acid sequences of CBG and of alpha 1-antitrypsin, and this extends to other members of the serpin (serine protease inhibitor) superfamily.
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erythro-9-[3-(2-Hydroxynonyl)]adenine is an inhibitor of sperm motility that blocks dynein ATPase and protein carboxylmethylase activities.
TLDR
The effects of erythro-9-[3-(2-hydroxynonyl)]adenine (EHNA) which, in combination with adenosine and homocysteine thiolactone, inhibits protein carboxylmethylase activity in monocytes inhibited sea urchin sperm motility and provided evidence for the similarity of the active site of the dynein ATPase in sea urchesin and rat spermatozoa.
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Mifepristone (RU 486)--a modulator of progestin and glucocorticoid action.
TLDR
These agents provide the most effective and safest means of medical abortion, and in addition they may be used for the treatment of patients with cancer, Cushing's syndrome, and gynecologic disorders and for contraception.
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Changes in the distribution of intermediate filaments in rat Sertoli cells during the seminiferous epithelium cycle and postnatal development
TLDR
Very little is known of its distributional changes during the seminiferous epithelium cycle and during postnatal development of intermediate filaments in mammalian Sertoli cells.
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The cDNA‐deduced primary structure of human sex hormone‐binding globulin and location of its steroid‐binding domain
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