Presenilins

Known as: Presenilin, Presenilins [Chemical/Ingredient] 
Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2017
05010015019822017

Papers overview

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Highly Cited
2009
Highly Cited
2009
Mutations in the presenilin genes are the main cause of familial Alzheimer's disease. Loss of presenilin activity and/or… (More)
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Highly Cited
2006
Highly Cited
2006
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder. Mutations in presenilins 1 and 2 (PS1 and… (More)
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Highly Cited
2004
Highly Cited
2004
Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and gamma-secretase to release amyloid peptides… (More)
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Highly Cited
2004
Highly Cited
2004
Mutations in presenilins are the major cause of familial Alzheimer's disease, but the pathogenic mechanism by which presenilin… (More)
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Highly Cited
1999
Highly Cited
1999
Signalling through the receptor protein Notch, which is involved in crucial cell-fate decisions during development, requires… (More)
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Highly Cited
1999
Highly Cited
1999
Accumulation of the amyloid-beta protein (Abeta) in the cerebral cortex is an early and invariant event in the pathogenesis of… (More)
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Highly Cited
1998
Highly Cited
1998
Genetic causes of Alzheimer's disease (AD) include mutations in the amyloid precursor protein (APP), presenilin 1 (PS1), and… (More)
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Highly Cited
1997
Highly Cited
1997
Missense mutations in two related genes, termed presenilin 1 (PS1) and presenilin 2 (PS2), cause dementia in a subset of early… (More)
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Highly Cited
1996
Highly Cited
1996
To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to… (More)
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Highly Cited
1996
Highly Cited
1996
Mutations in the genes encoding amyloid-beta precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) are known to… (More)
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