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Presenilins

Known as: Presenilin, Presenilins [Chemical/Ingredient] 
Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the… Expand
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Highly Cited
2006
Highly Cited
2006
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder. Mutations in presenilins 1 and 2 (PS1 and… Expand
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Highly Cited
2004
Highly Cited
2004
Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and gamma-secretase to release amyloid peptides… Expand
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Highly Cited
1999
Highly Cited
1999
Accumulation of the amyloid-β protein (Aβ) in the cerebral cortex is an early and invariant event in the pathogenesis of… Expand
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Highly Cited
1999
Highly Cited
1999
Signalling through the receptor protein Notch, which is involved in crucial cell-fate decisions during development, requires… Expand
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Highly Cited
1998
Highly Cited
1998
Genetic causes of Alzheimer's disease (AD) include mutations in the amyloid precursor protein (APP), presenilin 1 (PS1), and… Expand
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Review
1997
Review
1997
  • John Hardy
  • Trends in Neurosciences
  • 1997
  • Corpus ID: 36071618
Various mutations in the amyloid protein precursor and presenilin genes can lead to early onset, autosomal Alzheimer's disease. A… Expand
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Highly Cited
1997
Highly Cited
1997
The mechanism by which mutations in the presenilin (PS) genes cause the most aggressive form of early-onset Alzheimer's disease… Expand
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Highly Cited
1996
Highly Cited
1996
MUTATIONS in the genes encoding amyloid-β precursor protein (APP)1 presenilin 1 (PS1)2 and presenilin 2 (PS2)3,4 are known to… Expand
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Highly Cited
1996
Highly Cited
1996
Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of early-onset familial Alzheimer's… Expand
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