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Presenilins

Known as: Presenilin, Presenilins [Chemical/Ingredient] 
Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH… 
National Institutes of Health

Related topics

Related topics

10 relations
Alzheimer's DiseaseIn BloodProcess of secretionagonists

Broader (1)

Membrane Proteins

Papers overview

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Highly Cited
2011
Highly Cited
2011
Epigenetic mechanisms of amyloid-β production in anisomycin-treated SH-SY5Y cells
Highly Cited
2008
Highly Cited
2008
Effects of progesterone administration and APPswe+PSEN1Δe9 mutation for cognitive performance of mid-aged mice
Highly Cited
2007
Highly Cited
2007
Presenilin 1 Regulates Epidermal Growth Factor Receptor Turnover and Signaling in the Endosomal-Lysosomal Pathway*
Mutations in the gene encoding presenilin 1 (PS1) cause the most aggressive form of early-onset familial Alzheimer disease. In… 
Review
2005
Review
2005
Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease
Several lines of evidence indicate that the Aβ peptide is involved at some level in the pathological process that results in the… 
Review
2002
Review
2002
Secretases as targets for the treatment of Alzheimer's disease: the prospects
Highly Cited
2002
Highly Cited
2002
A New Splice Variant of Glial Fibrillary Acidic Protein, GFAPε, Interacts with the Presenilin Proteins*
We describe a new human isoform, GFAPε, of the intermediary filament protein GFAP (glial fibrillary acidic protein). GFAPε mRNA… 
Highly Cited
2000
Highly Cited
2000
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
The beta-amyloid precursor protein (beta-APP), which is involved in the pathogenesis of Alzheimer's disease, and the Notch… 
Highly Cited
2000
Highly Cited
2000
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
An unusual intramembranous cleavage of the beta-amyloid precursor protein (APP) by gamma-secretase is the final step in the… 
Review
1999
Review
1999
Recent advances on neuronal caspases in development and neurodegeneration
Highly Cited
1997
Highly Cited
1997
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Pathogenic mutations in presenilin 1 (PS1) are associated with approximately 50% of early-onset familial Alzheimer disease. PS1… 
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