Pregnenolone Carbonitrile

Known as: Pregnenolone Carbonitrile [Chemical/Ingredient], 16 alpha-Carbonitrile, Pregnenolone, Pregnenolone 16 alpha Carbonitrile 
A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the… (More)
National Institutes of Health

Papers overview

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2005
2005
The effect of liver growth stimulation [using the rodent PXR (pregnane X receptor) activator PCN (pregnenolone-16alpha… (More)
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Highly Cited
2004
Highly Cited
2004
P-glycoprotein, an ATP-driven drug export pump, is a critical, selective component of the blood-brain barrier responsible for the… (More)
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Highly Cited
2004
Highly Cited
2004
The nuclear receptors CAR and PXR activate hepatic genes in response to therapeutic drugs and xenobiotics, leading to the… (More)
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Highly Cited
2001
Highly Cited
2001
The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN… (More)
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Review
1999
Review
1999
The biochemistry of foreign compound metabolism and the roles played by individual cytochrome P450 (CYP) enzymes in drug… (More)
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1997
1997
We have studied the distribution of the neurosteroids pregnenolone (Pe) and pregnenolone sulfate (PeS) in seven brain regions… (More)
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Highly Cited
1988
Highly Cited
1988
Our earlier biochemical studies suggested that the neurosteroid pregnenolone sulfate (PS) may reduce gamma-aminobutyric acid… (More)
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1986
1986
A cytochrome P-450 cDNA clone, designated pP450PCN2, homologous to the previously characterized pregnenolone 16 alpha… (More)
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Highly Cited
1985
Highly Cited
1985
The individual members of a homologous series of phenoxazone ethers related to ethoxyresorufin were O-dealkylated, and the parent… (More)
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Highly Cited
1976
Highly Cited
1976
We previously hypothesized that the genetic trait of aromatic hydrocarbon nonresponsiveness (the failure in certain inbred… (More)
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