Cytosolic receptor for aryl hydrocarbon hydroxylase induction by polycyclic aromatic compounds. Evidence for structural and regulatory variants among established cell cultured lines.

@article{Guenthner1977CytosolicRF,
  title={Cytosolic receptor for aryl hydrocarbon hydroxylase induction by polycyclic aromatic compounds. Evidence for structural and regulatory variants among established cell cultured lines.},
  author={Thomas M. Guenthner and Daniel W. Nebert},
  journal={The Journal of biological chemistry},
  year={1977},
  volume={252 24},
  pages={8981-9}
}
The effective doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for inducing half-maximally (ED,, values) aryl hydrocarbon (benzolalpyrene) hydroxylase activity (EC 1.14.14.2) in H-4-11-E, Hepa-l, VERO, and HTC established cell culture lines are about 0.23, 0.45, 110, and >200 nM, respectively, and the maximally induced hydroxylase activity is more than 100 times higher in TCDD-treated H-4-11-E and Hepa-l than in VERO or HTC lines. The former two lines are therefore regarded as “responsive… CONTINUE READING

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