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Towards a consensus on diagnostic criteria, measurement and trial design of the premenstrual disorders: the ISPMD Montreal consensus
TLDR
An international multidisciplinary group of experts met at a face-to-face consensus meeting to review current definitions and diagnostic criteria for PMD to provide a unified approach for the diagnostic criteria, their quantification and guidelines on clinical trial design. Expand
Allopregnanolone inhibits learning in the Morris water maze
TLDR
The natural progesterone metabolite allopregnanolone can inhibit learning in the Morris water maze, an effect not caused by motor impairment, due to a combination of changed swimming behavior and difficulties in navigation. Expand
Patients with Premenstrual Syndrome Have a Different Sensitivity to a Neuroactive Steroid during the Menstrual Cycle Compared to Control Subjects
TLDR
Control subjects increased their SEV response to pregnanolone in the luteal phase compared to the follicular phase, whereas PMS patients did not, compatible with a decreased GABAA-receptor sensitivity in brain areas controlling saccadic eye movements among PMs patients in the late luteAL phase. Expand
Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators
TLDR
Findings suggest that negative mood symptoms in women with premenstrual dysphoric disorder (PMDD) are caused by the paradoxical effect of allopregnanolone mediated via the GABA(A) receptor. Expand
EPILEPTIC SEIZURES IN WOMEN RELATED to PLASMA ESTROGEN and PROGESTERONE DURING the MENSTRUAL CYCLE
TLDR
Nine periods in seven women with partial epilepsy have been investigated with respect to frequency of fits, and estrogen‐progesterone levels in blood plasma, and a positive correlation between the number of secondary generalized seizures and the mean estrogen/progestersterone ratios. Expand
Pathogenesis in Menstrual Cycle‐Linked CNS Disorders
TLDR
Animal and human studies show that GABA‐A receptor‐positive modulators like barbiturates, benzodiazepines, alcohol, and allopregnanolone have a bimodal effect, which can induce adverse emotional reactions in up to 20% of individuals and induce tolerance to themselves and similar substances. Expand
Progesterone selectively increases amygdala reactivity in women
TLDR
Investigating whether a single progesterone administration to healthy young women in their follicular phase modulates the amygdala response to salient, biologically relevant stimuli reveals a neural mechanism by which progester one may mediate adverse effects on anxiety and mood. Expand
Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms.
TLDR
The concomitant expression of PDGF and PDGFR alpha in tumor cells is related to progression of malignant ovarian tumors, indicating a functional role ofPDGF via autocrine growth stimulation. Expand
The Role of Hormones and Hormonal Treatments in Premenstrual Syndrome
TLDR
SSRIs and substances inhibiting ovulation, such as gonadotrophin-releasing hormone (GnRH) agonists, have proven to be effective treatments and add-back hormone replacement therapy is recommended to avoid adverse effects when high dosages of GnRH agonists are sed. Expand
ISPMD consensus on the management of premenstrual disorders
TLDR
The second consensus meeting of the International Society for Premenstrual Disorders took place in London during March 2011 and agreed that careful diagnosis based on the recommendations and classification derived from the first ISPMD consensus conference is essential and should underlie the appropriate management strategy. Expand
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