Phosphoinositide Phosphatases

Known as: Phosphatases, Phosphoinositide, Phosphoinositide Phosphatase, Phosphoinositide Phosphatases [Chemical/Ingredient] 
Phosphatases that catalyze the hydrolysis of phosphate groups on PHOSPHATIDYLINOSITOLS.
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS.
Mutations of the lipid phosphatase FIG4 that regulates PI(3,5)P(2) are responsible for the recessive peripheral-nerve disorder… (More)
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Highly Cited
2007
Highly Cited
2007
Depolarization activates the phosphoinositide phosphatase Ci-VSP, as detected in Xenopus oocytes coexpressing sensors of PIP2.
Voltage-evoked signals play critical roles in neural activities, muscle contraction and exocytosis. Ciona voltage-sensor… (More)
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Highly Cited
2005
Highly Cited
2005
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor
Changes in membrane potential affect ion channels and transporters, which then alter intracellular chemical conditions. Other… (More)
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Highly Cited
2004
Highly Cited
2004
Salmonella modulates vesicular traffic by altering phosphoinositide metabolism.
Salmonella enterica, the cause of food poisoning and typhoid fever, induces actin cytoskeleton rearrangements and membrane… (More)
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Highly Cited
2004
Highly Cited
2004
Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase.
In the budding yeast Saccharomyces cerevisiae, phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is synthesized by a single… (More)
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Highly Cited
2003
Highly Cited
2003
Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts.
We describe a novel approach to quantitation of phosphoinositides in cell extracts and in vitro enzyme-catalyzed reactions using… (More)
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Highly Cited
2003
Highly Cited
2003
Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry
Phosphoinositides (phosphorylated derivatives of phosphatidylinositol, PI) are versatile intracellular signaling lipids whose… (More)
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Highly Cited
2001
Highly Cited
2001
Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve.
The dual specificity mammalian enzyme PIKfyve phosphorylates in vitro position d-5 in phosphatidylinositol (PtdIns) and PtdIns 3… (More)
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Highly Cited
2000
Highly Cited
2000
Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay.
The tumor suppressor gene PTEN is frequently mutated in diverse human cancers and in autosomal dominant cancer predisposition… (More)
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Highly Cited
1997
Highly Cited
1997
Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide.
Phosphoinositide 3-kinase (PI 3-kinase) is a key signaling enzyme implicated in variety of receptor-stimulated cell responses… (More)
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