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A Human Genome Diversity Cell Line Panel
A resource of 1064 cultured lymphoblastoid cell lines (LCLs) () from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation Jean…
Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics
- D. Gurwitz
- BiologyDrug development research
- 4 March 2020
This commentary elaborates on the idea of considering AT1R blockers as tentative treatment for SARS‐CoV‐2 infections, and proposes a research direction based on datamining of clinical patient records for assessing its feasibility.
The genome-wide structure of the Jewish people
High-density bead arrays to genotype individuals from 14 Jewish Diaspora communities are used to compare patterns of genome-wide diversity with those from 69 Old World non-Jewish populations, of which 25 have not previously been reported.
Refined Geographic Distribution of the Oriental ALDH2*504Lys (nee 487Lys) Variant
It is concluded that ALDH2*504Lys was carried by Han Chinese as they spread throughout East Asia, and occurs in most areas of China, Japan, Korea, Mongolia, and Indochina with frequencies gradually declining radially from Southeast China.
Single Nucleotide Polymorphism of the Human High Affinity Choline Transporter Alters Transport Rate*
- T. Okuda, M. Okamura, C. Kaitsuka, T. Haga, D. Gurwitz
- BiologyThe Journal of Biological Chemistry
- 22 November 2002
The presence of functionally relevant, nonsynonymous single nucleotide polymorphism in the human CHT1 gene is demonstrated by comprehensive sequence analysis of the exons and the intron/exon boundaries including the transcription start site.
Counting the Founders: The Matrilineal Genetic Ancestry of the Jewish Diaspora
The numerically major portion of the non-Ashkenazi Jews, currently estimated at 5 million people and comprised of the Moroccan, Iraqi, Iranian and Iberian Exile Jewish communities showed no evidence for a narrow founder effect, which did however characterize the smaller and more remote Belmonte, Indian and the two Caucasus communities.
The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event.
It is shown that close to one-half of Ashkenazi Jews can be traced back to only 4 women carrying distinct mtDNAs that are virtually absent in other populations, with the important exception of low frequencies among non-Ashkenazi Jewry.
Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc.
MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish population
Diversity patterns in mitochondrial DNA (mtDNA) hypervariable segment 1 (HVS-1) sequence and restriction site polymorphisms in 565 Ashkenazi Jews from different parts of Europe provide evidence for a prolonged period of low effective size in the history of theAshkenazi population.