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The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.
Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that p140prototrk binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. Expand
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
Tyrosine phosphorylation of trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF. Expand
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
Reconstitution experiments reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor and the tyrosine kinase trk gene product. Expand
Molecular and biochemical characterization of the human trk proto-oncogene.
- D. Martín-Zanca, R. Oskam, G. Mitra, T. Copeland, M. Barbacid
- Biology, Medicine
- Molecular and cellular biology
Results indicate that the product of the human trk locus is a novel tyrosine kinase cell surface receptor for an as yet unknown ligand. Expand
Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system.
The expression of trkB, a TK receptor, in early embryogenesis, and specifically in neural tissues, is consistent with the notion that this gene plays a role in the events that regulate the development of the nervous system. Expand
Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats
Each of the Ha-ras-1 oncogenes present in tumours induced by N-nitroso-N-methylurea, but not in those induced by 7,12-dimethylbenz(a)anthracene, became activated by the same G → A transition, the type of mutation induced by W → N → G → M transition. Expand
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase.… Expand
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.
Nucleotide sequence analysis of this vav oncogene cDNA clone revealed that its 5′ 167 bp were derived from pSV2neo DNA cotransfected as a selectable marker during gene transfer, indicating that this novel locus might play an important role in hematopoiesis. Expand
Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations
Results indicate that chemical carcinogenesis represents an adequate model to study the role of transforming ras genes in human neoplasia and that the twelfth codon was GAA instead of GGA of the normal allele, encoding glutamic acid in place of glycine. Expand
Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.
- M. Vetter, D. Martín-Zanca, L. Parada, J. Bishop, D. Kaplan
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 July 1991
These findings identify PLC-gamma 1 as a likely substrate for the trk-encoded tyrosine kinase, and they provide a link between NGF-dependent activation of p140trk and the stimulation of intracellular second messenger pathways. Expand