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Phosphoinositide Pathway

Known as: Phosphoinositides and their downstream targets 
Nine currently identified phosphoinositide 3-kinases (PI 3-K) constitute a subfamily of lipid kinases that catalyze the addition of a phosphate… 
National Institutes of Health

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19 relations
AKT1 wt AlleleARHGEF2 wt AlleleBAD wt AlleleBad protein

Papers overview

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Review
2014
Review
2014
Endothelin-1 signaling in vascular physiology and pathophysiology.
The discovery of endothelin (ET) in 1988 has led to considerable effort to unravel its implication in health and disease and the… 
Review
2002
Review
2002
Regulation of Ca2+ entry pathways by both limbs of the phosphoinositide pathway.
All inositol 1,4,5-trisphosphate (InsP3) receptors are biphasically regulated by cytosolic Ca2+. For type 2 InsP3 receptors… 
Highly Cited
1997
Highly Cited
1997
Clustering the adhesion molecules VLA‐4 (CD49d/CD29) in Jurkat T cells or VCAM‐1 (CD106) in endothelial (ECV 304) cells activates the phosphoinositide pathway and triggers Ca2+ mobilization
Ligation of very late antigen (VLA)‐4 (α4β1 integrin) with a cross‐linked anti‐α4 subunit monoclonal antibody (mAb) triggered a… 
1997
1997
Modification of heart sarcolemmal phosphoinositide pathway by lysophosphatidylcholine.
1996
1996
Galactocerebroside mediated transmembrane Ca2+ signalling in U-87 MG cells: Possible involvement of phosphoinositides
Antibody to galactocerebroside (anti- GalC) has been shown to evoke a Ca2+ response in cultured glioma U- 87 MG cells. The rise… 
1996
1996
Mechanisms underlying the vascular activity of beta-amyloid protein fragment (beta A(4)25-35) at the level of skin microvasculature.
Deposition of beta-amyloid protein (beta A4) in extracellular senile plaques is a pathologic hallmark of Alzheimer's disease (AD… 
1995
1995
Role of Na+/phosphate-cotransporter in myocardial contractile responses to alpha 1-agonist.
The interaction of cardiac sodium/phosphate (Na+/Pi)-cotransporter and the phosphoinositide pathway (PIP) in influencing… 
Highly Cited
1991
Highly Cited
1991
Angiotensin-induced desensitization of the phosphoinositide pathway in cardiac cells occurs at the level of the receptor.
Previous studies show that angiotensin II (Ang II) increases phosphoinositide turnover in cultured neonatal heart cells. Ang II… 
1991
1991
Studies of inositol analogues as inhibitors of the phosphoinositide pathway, and incorporation of 2-deoxy-2-fluoro-myo-inositol to give analogues of phosphatidylinositol intermediates.
The incorporation of [3H]Ins into PtdIns by exchange of free and lipid-bound inositol moieties occurs via the action of at least… 
Highly Cited
1987
Highly Cited
1987
Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism.
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