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Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome
TLDR
Although ranolazine alone prolonged APD, it reduced APD and ventricular arrhythmias caused by agents that increased late INa and decreased IK, and attenuated the synergistic effect of MAPD90 increase caused by combinations of ATX-II and blockers of IK. Expand
Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro
TLDR
It is found that for PC-12, HeLa and HT-29 cell lines as well as primary cultures of cardiac myocytes and neurons in vitro in differing media, approximately 5 nmol/L free zinc produced apparently healthy cells, but 20-fold higher or lower concentrations were usually harmful as judged by multiple criteria. Expand
Angiotensin II-evoked enhanced expression of RGS2 attenuates Gi-mediated adenylyl cyclase signaling in A10 cells.
TLDR
The results suggest that RGS2 may be involved in short-term regulation of Ang II-induced Gi-mediated adenylyl cyclase signalling. Expand
Histone deacetylase inhibition by sodium valproate regulates polarization of macrophage subsets.
TLDR
It is demonstrated that VPA significantly affects the phenotype and function of macrophage, indicating an important role of HDAC activity in immune regulation and inflammation and provides a rationale to evaluate VPA activity for the treatment of macophage dysfunction-associated diseases. Expand
G protein-linked cell signaling and cardiovascular functions in diabetes/hyperglycemia
TLDR
G protein-adenylyl cyclase signaling that plays an important role in the regulation of cardiovascular functions also has been reported to be impaired in diabetes and under hyperglycemic conditions. Expand
Transient fluctuations of intracellular zinc ions in cell proliferation.
TLDR
Fluctuated fluctuations of intracellular Zn(2+) concentrations and established modulation of phosphorylation signaling, via an inhibition of protein tyrosine phosphatases at commensurately low ZN( 2+) concentrations, suggest a role for Zn (2+) in the control of the cell cycle. Expand
Epidermal growth factor receptor transactivation by endogenous vasoactive peptides contributes to hyperproliferation of vascular smooth muscle cells of SHR.
TLDR
Ex vivo vasoactive peptides, through increased oxidative stress and resultant activation of c-Src, transactivate EGF-R, which through mitogen-activated protein (MAP) kinase signaling may contribute to the hyperproliferation of VSMC from SHR. Expand
Small cytoplasmic domain peptides of natriuretic peptide receptor-C attenuate cell proliferation through Gialpha protein/MAP kinase/PI3-kinase/AKT pathways.
TLDR
C-ANP and small peptide fragments containing 12 amino acids inhibit proliferative responses of vasoactive peptides through G(i)alpha protein and MAP kinase/phosphatidylinositol 3-kinase/AKT pathways. Expand
Transactivation of epidermal growth factor receptor by enhanced levels of endogenous angiotensin II contributes to the overexpression of Giα proteins in vascular smooth muscle cells from SHR.
TLDR
The results suggest that the enhanced levels of endogenous Ang II in VSMC from SHR, transactivate EGFR, which through MAP kinase signaling, enhance the expression of Giα proteins and associated adenylyl cyclase signaling. Expand
High-mobility group box 1 released from astrocytes promotes the proliferation of cultured neural stem/progenitor cells
TLDR
HMGB1 released by reactive astrocytes promoted NS/PC proliferation by binding RAGE and enhancing the phosphorylation of the JNK signaling pathway, and this findings support a previously described mechanism of a crosstalk between astroCytes and NS/ PCs, and suggest that reactiveAstrocyte-derived HMGB1 plays an important role in the repair of the central nervous system following brain injury. Expand
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