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Sodium/calcium exchange: its physiological implications.
The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane (PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ pump. As aExpand
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Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle.
Spontaneous local increases in the concentration of intracellular calcium, called "calcium sparks," were detected in quiescent rat heart cells with a laser scanning confocal microscope and theExpand
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Calcium sparks in smooth muscle.
Local intracellular Ca(2+) transients, termed Ca(2+) sparks, are caused by the coordinated opening of a cluster of ryanodine-sensitive Ca(2+) release channels in the sarcoplasmic reticulum of smoothExpand
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The control of calcium release in heart muscle.
The control of calcium release from intracellular stores (the sarcoplasmic reticulum) in cardiac muscle was examined with the use of a confocal microscope and voltage clamp techniques. DepolarizationExpand
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X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart
Reactive oxygen species produced by NADPH oxidase link mechanical stretching to calcium signaling in mammalian myocytes. We report that in heart cells, physiologic stretch rapidly activatesExpand
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Calcium sparks and [Ca2+]i waves in cardiac myocytes.
Local elevations in intracellular calcium ("Ca2+ sparks") in heart muscle are elementary sarcoplasmic reticulum (SR) Ca(2+)-release events. Ca2+ sparks occur at a low rate in quiescent cells but canExpand
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Calcium sparks.
The calcium ion (Ca(2+)) is the simplest and most versatile intracellular messenger known. The discovery of Ca(2+) sparks and a related family of elementary Ca(2+) signaling events has revealedExpand
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A simple numerical model of calcium spark formation and detection in cardiac myocytes.
The elementary events of excitation-contraction coupling in heart muscle are Ca2+ sparks, which arise from one or more ryanodine receptors in the sarcoplasmic reticulum (SR). Here a simple numericalExpand
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Cloning and expression of an inwardly rectifying ATP-regulated potassium channel
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanningExpand
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Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure.
Cardiac hypertrophy and heart failure caused by high blood pressure were studied in single myocytes taken from hypertensive rats (Dahl SS/Jr) and SH-HF rats in heart failure. Confocal microscopy andExpand
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