• Publications
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Inositol trisphosphate and calcium signaling.
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IP3 receptors and their regulation by calmodulin and cytosolic Ca2+.
Inositol 1,4,5-trisphosphate (IP(3)) receptors are tetrameric intracellular Ca(2+) channels, the opening of which is regulated by both IP(3) and Ca(2+). We suggest that all IP(3) receptors areExpand
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A non‐capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin
1 Depletion of the Ca2+ stores of A7r5 cells stimulated Ca2+, though not Sr2+, entry. Vasopressin (AVP) or platelet‐derived growth factor (PDGF) stimulated Sr2+ entry. The cells therefore express aExpand
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Structural and functional conservation of key domains in InsP3 and ryanodine receptors
Inositol-1,4,5-trisphosphate receptors (InsP3Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca2+ channels. In each of these receptor families, the pore, which is formed byExpand
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  • PDF
The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor.
The thiol reagent, thimerosal, has been shown to cause an increase in intracellular Ca2+ concentration ([Ca2+]i) in several cell types, and to cause Ca2+ spikes in unfertilized hamster eggs. UsingExpand
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IP(3) receptors: toward understanding their activation.
  • C. Taylor, S. Tovey
  • Biology, Medicine
  • Cold Spring Harbor perspectives in biology
  • 1 December 2010
Inositol 1,4,5-trisphosphate receptors (IP(3)R) and their relatives, ryanodine receptors, are the channels that most often mediate Ca(2+) release from intracellular stores. Their regulation by Ca(2+)Expand
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Pharmacological analysis of intracellular Ca2+ signalling: problems and pitfalls.
  • C. Taylor, L. Broad
  • Biology, Medicine
  • Trends in pharmacological sciences
  • 1 September 1998
The complex changes in intracellular Ca2+ concentration that follow cell stimulation reflect the concerted activities of Ca2+ channels in the plasma membrane and in the membranes of intracellularExpand
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Expression of inositol trisphosphate receptors.
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An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+ Signals*
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger proposed to stimulate Ca2+ release from acidic organelles via two-pore channels (TPCs). It has been difficult toExpand
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Identification of Intracellular and Plasma Membrane Calcium Channel Homologues in Pathogenic Parasites
Ca2+ channels regulate many crucial processes within cells and their abnormal activity can be damaging to cell survival, suggesting that they might represent attractive therapeutic targets inExpand
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