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Inositol trisphosphate and calcium signaling.
IP3 receptors and their regulation by calmodulin and cytosolic Ca2+.
Inositol 1,4,5-trisphosphate (IP(3)) receptors are tetrameric intracellular Ca(2+) channels, the opening of which is regulated by both IP(3) and Ca(2+). We suggest that all IP(3) receptors are… Expand
A non‐capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin
1 Depletion of the Ca2+ stores of A7r5 cells stimulated Ca2+, though not Sr2+, entry. Vasopressin (AVP) or platelet‐derived growth factor (PDGF) stimulated Sr2+ entry. The cells therefore express a… Expand
Structural and functional conservation of key domains in InsP3 and ryanodine receptors
Inositol-1,4,5-trisphosphate receptors (InsP3Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca2+ channels. In each of these receptor families, the pore, which is formed by… Expand
The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor.
- M. Bootman, C. Taylor, M. Berridge
- Medicine, Chemistry
- The Journal of biological chemistry
- 15 December 1992
The thiol reagent, thimerosal, has been shown to cause an increase in intracellular Ca2+ concentration ([Ca2+]i) in several cell types, and to cause Ca2+ spikes in unfertilized hamster eggs. Using… Expand
IP(3) receptors: toward understanding their activation.
Inositol 1,4,5-trisphosphate receptors (IP(3)R) and their relatives, ryanodine receptors, are the channels that most often mediate Ca(2+) release from intracellular stores. Their regulation by Ca(2+)… Expand
Pharmacological analysis of intracellular Ca2+ signalling: problems and pitfalls.
The complex changes in intracellular Ca2+ concentration that follow cell stimulation reflect the concerted activities of Ca2+ channels in the plasma membrane and in the membranes of intracellular… Expand
Expression of inositol trisphosphate receptors.
An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+ Signals*
- E. Brailoiu, T. Rahman, +5 authors S. Patel
- Biology, Medicine
- The Journal of Biological Chemistry
- 29 September 2010
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger proposed to stimulate Ca2+ release from acidic organelles via two-pore channels (TPCs). It has been difficult to… Expand
Identification of Intracellular and Plasma Membrane Calcium Channel Homologues in Pathogenic Parasites
Ca2+ channels regulate many crucial processes within cells and their abnormal activity can be damaging to cell survival, suggesting that they might represent attractive therapeutic targets in… Expand