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Phosphodiesterase 4 Inhibitors
Known as:
PDE 4 Inhibitors
, Inhibitors, Phosphodiesterase 4
, Phosphodiesterase Type 4 Inhibitors
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Compounds that specifically inhibit PHOSPHODIESTERASE 4.
National Institutes of Health
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Related topics
Related topics
11 relations
Narrower (6)
Cilomilast
KW 4490
MK 0873
Rolipram
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In Blood
Phosphodiesterase 4 Inhibitor [EPC]
aspects of radiation effects
chemical synthesis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression.
J. Cashman
,
T. Voelker
,
Robert A. Johnson
,
A. Janowsky
Bioorganic & Medicinal Chemistry
2009
Corpus ID: 45924411
Highly Cited
2008
Highly Cited
2008
Antipsychotic-Like Properties of Phosphodiesterase 4 Inhibitors: Evaluation of 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone (RO-20-1724) with Auditory Event-Related Potentials and Prepulse…
Tobias Halene
,
S. Siegel
Journal of Pharmacology and Experimental…
2008
Corpus ID: 1087506
Antipsychotic medications function through antagonism of D2 dopamine receptors. Blockade of D2 receptors causes an increase in…
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2005
2005
Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PET
M. Fujita
,
S. Zoghbi
,
+13 authors
R. Innis
NeuroImage
2005
Corpus ID: 31308363
2004
2004
The Type IV phosphodiesterase inhibitor rolipram interferes with drug‐induced conditioned place preference but not immediate early gene induction in mice
B. E. Thompson
,
Benjamin D. Sachs
,
K. Kantak
,
J. Cherry
European Journal of Neuroscience
2004
Corpus ID: 36374989
Behavioural effects of psychostimulant and opiate drugs are mediated in part by cAMP pathways operating in the nucleus accumbens…
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Review
2002
Review
2002
Phosphodiesterase 4 inhibitors for the treatment of COPD.
G. Sturton
,
M. Fitzgerald
Chest
2002
Corpus ID: 39971354
Phosphodiesterase 4 (PDE4) is a major cyclic adenosine-3',5'-monophosphate-metabolizing enzyme in immune and inflammatory cells…
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Highly Cited
2002
Highly Cited
2002
Characterisation of cyclic nucleotide phosphodiesterase isoforms in the media layer of the main pulmonary artery.
O. Pauvert
,
D. Salvail
,
É. Rousseau
,
C. Lugnier
,
R. Marthan
,
J. Savineau
Biochemical Pharmacology
2002
Corpus ID: 44678803
Highly Cited
2000
Highly Cited
2000
Effects of Repeated Antidepressant Treatment on Type 4A Phosphodiesterase (PDE4A) in Rat Brain
Ying Ye
,
K. Jackson
,
J. O'Donnell
Journal of Neurochemistry
2000
Corpus ID: 36339928
In a previous study, an up‐regulation of rolipram‐sensitive, low‐Km, cyclic AMP phosphodiesterase (PDE4) subtype PDE4A in rat…
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Review
2000
Review
2000
New phosphodiesterase inhibitors as therapeutics for the treatment of chronic lung disease.
M. Barnette
,
David C. Underwood
Current opinion in pulmonary medicine
2000
Corpus ID: 24216393
Phosphodiesterase 4 (PDE4) is a member of the growing family cyclic AMP and cyclic GMP. Earliest described inhibitors of PDE4…
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1999
1999
Effects of rolipram on the elevated plus-maze test in rats: a preliminary study
J. Silvestre
,
Andrés G. Fernández
,
J. Palacios
Journal of Psychopharmacology
1999
Corpus ID: 45365111
The objective of the present study was to assess the behavioural effects of rolipram, a specific cAMP phosphodiesterase (PDE4…
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Highly Cited
1998
Highly Cited
1998
Thalidomide analogs and PDE4 inhibition.
G. Muller
,
Mary G. Shire
,
+4 authors
D. Stirling
Bioorganic & Medicinal Chemistry Letters
1998
Corpus ID: 36858861
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