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Phosphodiesterase 4 Inhibitors

Known as: PDE 4 Inhibitors, Inhibitors, Phosphodiesterase 4, Phosphodiesterase Type 4 Inhibitors 
Compounds that specifically inhibit PHOSPHODIESTERASE 4.
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (6)

CilomilastKW 4490MK 0873Rolipram
In BloodPhosphodiesterase 4 Inhibitor [EPC]aspects of radiation effectschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression.
Highly Cited
2008
Highly Cited
2008
Antipsychotic-Like Properties of Phosphodiesterase 4 Inhibitors: Evaluation of 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone (RO-20-1724) with Auditory Event-Related Potentials and Prepulse…
Antipsychotic medications function through antagonism of D2 dopamine receptors. Blockade of D2 receptors causes an increase in… 
2005
2005
Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PET
2004
2004
The Type IV phosphodiesterase inhibitor rolipram interferes with drug‐induced conditioned place preference but not immediate early gene induction in mice
Behavioural effects of psychostimulant and opiate drugs are mediated in part by cAMP pathways operating in the nucleus accumbens… 
Review
2002
Review
2002
Phosphodiesterase 4 inhibitors for the treatment of COPD.
Phosphodiesterase 4 (PDE4) is a major cyclic adenosine-3',5'-monophosphate-metabolizing enzyme in immune and inflammatory cells… 
Highly Cited
2002
Highly Cited
2002
Characterisation of cyclic nucleotide phosphodiesterase isoforms in the media layer of the main pulmonary artery.
Highly Cited
2000
Highly Cited
2000
Effects of Repeated Antidepressant Treatment on Type 4A Phosphodiesterase (PDE4A) in Rat Brain
In a previous study, an up‐regulation of rolipram‐sensitive, low‐Km, cyclic AMP phosphodiesterase (PDE4) subtype PDE4A in rat… 
Review
2000
Review
2000
New phosphodiesterase inhibitors as therapeutics for the treatment of chronic lung disease.
Phosphodiesterase 4 (PDE4) is a member of the growing family cyclic AMP and cyclic GMP. Earliest described inhibitors of PDE4… 
1999
1999
Effects of rolipram on the elevated plus-maze test in rats: a preliminary study
The objective of the present study was to assess the behavioural effects of rolipram, a specific cAMP phosphodiesterase (PDE4… 
Highly Cited
1998
Highly Cited
1998
Thalidomide analogs and PDE4 inhibition.
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