Phosphodiesterase 4 Inhibitors

Known as: PDE 4 Inhibitors, Inhibitors, Phosphodiesterase 4, Phosphodiesterase Type 4 Inhibitors 
Compounds that specifically inhibit PHOSPHODIESTERASE 4.
National Institutes of Health

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CilomilastKW 4490MK 0873Rolipram
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In BloodPhosphodiesterase 4 Inhibitor [EPC]aspects of radiation effectschemical synthesis
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Papers overview

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Highly Cited
2012
Highly Cited
2012
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and… (More)
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Highly Cited
2007
Highly Cited
2007
Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity
Currently available antipsychotic medications work primarily by antagonizing D2 dopamine receptors, thus raising intracellular… (More)
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Review
2007
Review
2007
Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis.
The phosphodiesterase (PDE) 4 is the predominant cyclic AMP degrading enzyme in a variety of inflammatory cells including… (More)
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Highly Cited
2005
Highly Cited
2005
Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.
Cyclic nucleotide signaling functions as a negative modulator of inflammatory cell responses, and type 4 phosphodiesterases (PDE4… (More)
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Highly Cited
2004
Highly Cited
2004
The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery.
Although there is no spontaneous regeneration of mammalian spinal axons after injury, they can be enticed to grow if cAMP is… (More)
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Review
2003
Review
2003
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.
cAMP is a second messenger that controls many key cellular functions. The only way to inactivate cAMP is to degrade it through… (More)
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Highly Cited
2003
Highly Cited
2003
A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4.
Mice carrying a truncated form of cAMP-responsive element binding protein (CREB)-binding protein (CBP) show several developmental… (More)
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Review
2003
Review
2003
Phosphodiesterase-4 Inhibitors in the Treatment of Inflammatory Lung Disease
Phosphodiesterases (PDE) belong to an important family of proteins that regulate the intracellular levels of cyclic nucleotide… (More)
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Highly Cited
2002
Highly Cited
2002
Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis.
A combination of pharmacological and genetic approaches was used to determine the role of type 4 cAMP-specific cyclic nucleotide… (More)
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Highly Cited
1999
Highly Cited
1999
The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform.
The WD-repeat protein receptor for activated C-kinase (RACK1) was identified by its interaction with the cyclic AMP-specific… (More)
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