Phosphodiesterase 4 Inhibitors

Known as: PDE 4 Inhibitors, Inhibitors, Phosphodiesterase 4, Phosphodiesterase Type 4 Inhibitors 
Compounds that specifically inhibit PHOSPHODIESTERASE 4.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and… (More)
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Highly Cited
2007
Highly Cited
2007
Currently available antipsychotic medications work primarily by antagonizing D2 dopamine receptors, thus raising intracellular… (More)
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Review
2007
Review
2007
The phosphodiesterase (PDE) 4 is the predominant cyclic AMP degrading enzyme in a variety of inflammatory cells including… (More)
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Highly Cited
2005
Highly Cited
2005
Cyclic nucleotide signaling functions as a negative modulator of inflammatory cell responses, and type 4 phosphodiesterases (PDE4… (More)
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Highly Cited
2004
Highly Cited
2004
Although there is no spontaneous regeneration of mammalian spinal axons after injury, they can be enticed to grow if cAMP is… (More)
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Review
2003
Review
2003
cAMP is a second messenger that controls many key cellular functions. The only way to inactivate cAMP is to degrade it through… (More)
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Highly Cited
2003
Highly Cited
2003
Mice carrying a truncated form of cAMP-responsive element binding protein (CREB)-binding protein (CBP) show several developmental… (More)
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Review
2003
Review
2003
Phosphodiesterases (PDE) belong to an important family of proteins that regulate the intracellular levels of cyclic nucleotide… (More)
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Highly Cited
2002
Highly Cited
2002
A combination of pharmacological and genetic approaches was used to determine the role of type 4 cAMP-specific cyclic nucleotide… (More)
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Highly Cited
1999
Highly Cited
1999
The WD-repeat protein receptor for activated C-kinase (RACK1) was identified by its interaction with the cyclic AMP-specific… (More)
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