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Rolipram

Known as: (R,S)-Rolipram, Rolipram [Chemical/Ingredient], (+/-)-Rolipram 
A phosphodiesterase 4 inhibitor with antidepressant properties.
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

Antidepressive AgentsPhosphodiesterase 4 Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

ZK-62711

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2000
Review
2000
New phosphodiesterase inhibitors as therapeutics for the treatment of chronic lung disease.
Phosphodiesterase 4 (PDE4) is a member of the growing family cyclic AMP and cyclic GMP. Earliest described inhibitors of PDE4… 
1998
1998
Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains.
Several previous studies have demonstrated that the phosphodiesterase 4 selective inhibitor rolipram affects cellular function at… 
1993
1993
High Selectivity for Inhibition of Phosphodiesterase III and Positive Inotropic Effects of MCI‐154 in Guinea Pig Myocardium
MCI-154 (0.3–100 μM) exerted a concentration-dependent positive inotropic effect in isolated guinea pig papillary muscles (EC50 0… 
Highly Cited
1990
Highly Cited
1990
Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells.
Two cyclic nucleotide phosphodiesterase (PDE) activities were identified in pig aortic endothelial cells, a cyclic GMP-stimulated… 
1990
1990
The acute toxic effect of the phosphodiesterase inhibitor rolipram on plasma osmolality.
In view of the wide ranging functions of cyclic AMP as a second messenger, including osmoregulation, we have studied the acute… 
1990
1990
The pharmacodynamic action of the cyclic AMP phosphodiesterase inhibitor rolipram on prolactin producing rat pituitary adenoma (GH4C1) cells
Rolipram (4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone) represents a new class of specific low Km cAMP phosphodiesterase… 
1988
1988
A study to assess the anticholinergic activity of rolipram in healthy elderly volunteers.
Rolipram is an antidepressant with a novel mechanism of action: enhanced noradrenaline (first messenger) synthesis and release… 
1987
1987
Rolipram as a discriminative stimuli: transfer to phosphodiesterase inhibitors.
Rats were trained to discriminate (+/-)-rolipram (0.32 mg/kg, i.p.) from saline in a two-lever food-reinforced drug… 
Highly Cited
1986
Highly Cited
1986
Somatomedin-C as an amplifier of follicle-stimulating hormone action: enhanced accumulation of adenosine 3',5'-monophosphate.
Somatomedin-C (Sm-C) has recently been found to amplify the FSH-mediated acquisition of granulosa cell progestin biosynthetic… 
1986
1986
The role of spinal cord cyclic AMP in the acoustic startle response in rats
Drugs thought to increase intracellular levels of cAMP were infused intrathecally into the subarachnoid space of the lumbar… 
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