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Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells.
TLDR
Tryptase could provide an important stimulus for SMC proliferation in asthmatic airways, byacting on proteinase-activated receptor-2 (PAR-2), by acting on PAR-2.
Role of reactive oxygen species and gp91phox in endothelial dysfunction of pulmonary arteries induced by chronic hypoxia
TLDR
In extrapul pulmonary arteries from hypoxic mice, endothelium‐dependent relaxation appears to be mediated by ROS, in a gp91phox‐independent manner, and in intrapulmonary arteries, endothelial dysfunction depends on gp 91phox, the latter being rather the trigger than the mediator of impaired endothelial NO‐dependent relaxations.
Pneumothoraces and chest tube placement after CT-guided transthoracic lung biopsy using a coaxial technique: incidence and risk factors.
TLDR
Lesion depth is the predominant risk factor for pneumothorax in patients undergoing CT-guided transthoracic lung biopsy in patients with severe emphysema, obstructive lung disease, or hyperinflation.
The Pivotal Role of Airway Smooth Muscle in Asthma Pathophysiology
TLDR
The pivotal role of airway smooth muscle (ASM) in the pathophysiology of asthma is reviewed to review the mechanisms of AHR in asthma and how ASM remodelling represents a key feature of asthmatic bronchial remodelling.
Airway wall thickness in cigarette smokers: quantitative thin-section CT assessment.
TLDR
This software provides accurate and reproducible measurements of IA and WA of bronchi on thin-section CT images and demonstrates that in vivo normalized airway wall thickness was larger in smokers with COPD than it was in smokers or nonsmokers without COPD.
Assessment of bronchial wall thickness and lumen diameter in human adults using multi‐detector computed tomography: comparison with theoretical models
TLDR
In vivo values of cross‐sectional wall area, lumen area, wall thickness and lumen diameter in ten healthy subjects as assessed by multi‐detector computed tomography may help to improve knowledge of bronchial anatomy in vivo, the understanding of the pathophysiology of Bronchial diseases and the evaluation of pharmacological effects on the bronchian wall.
Pathophysiology of bronchial smooth muscle remodelling in asthma
TLDR
The article will review recent data regarding the pathophysiology of bronchial smooth muscle remodelling in asthma and highlight the need to understand the mechanisms behind this remodelling.
Bronchial measurements in patients with asthma: comparison of quantitative thin-section CT findings with those in healthy subjects and correlation with pathologic findings.
TLDR
Axial reconstructions with orthogonal measurements along the airways enabled by three-dimensional segmentation methods are able to demonstrate significant changes in bronchial morphometry, predicting airflow limitation in asthma, and may have a role in the noninvasive measurement of airway remodeling.
Biphasic effect of extracellular ATP on human and rat airways is due to multiple P2 purinoceptor activation
TLDR
Extracellular ATP induces a transient contractile response in human and rat airways, mainly due to P2X receptors and extracellular Ca2+ influx in addition with, in IPB, P2Y receptors stimulation andCa2+ release from intracellular Ca 2+ stores.
Inflammation of bronchial smooth muscle in allergic asthma
TLDR
In asthma, airway myositis is characterised by a direct interaction between AsM cells and mast cells and lymphocytes, including cell hypertrophy and abnormal extracellular matrix deposition moulding ASM cells.
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