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Cilomilast

Known as: 4-cyano-4-(3-cyclopentoxy-4-methoxy-phenyl)-cyclohexane-1- carboxylic acid, Cilomilast [Chemical/Ingredient], Cis-4-Cyano-4-(3-(Cyclopentyloxy)-4-Methoxyphenyl)Cyclohexanecarboxylic Acid 
 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Apremilast, an oral small molecule inhibitor of phosphodiesterase 4 (PDE4), is in development for chronic inflammatory disorders… Expand
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Highly Cited
2012
Highly Cited
2012
  • P. Schafer
  • Biochemical pharmacology
  • 2012
  • Corpus ID: 19442410
Psoriasis and psoriatic arthritis are common clinical conditions that negatively impact health-related quality of life and are… Expand
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Highly Cited
2006
Highly Cited
2006
Background COPD is a relentless, progressive disease. This study evaluated the efficacy of cilomilast, a selective… Expand
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Review
2005
Review
2005
Inhibitors of phosphodiesterase type 4 (PDE4) act by increasing intracellular concentrations of cyclic AMP, which has a broad… Expand
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Highly Cited
2003
Highly Cited
2003
Cilomilast (Ariflo), a new oral phosphodiesterase-4 selective inhibitor, improves lung function in chronic obstructive pulmonary… Expand
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Highly Cited
2003
Highly Cited
2003
Background: Inflammation in chronic obstructive pulmonary disease (COPD) is characterised by increased neutrophilic infiltration… Expand
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Review
2002
Review
2002
Phosphodiesterase (PDE) enzymes are responsible for the inactiviation of cyclic adenosine monophosphate (cAMP) and cyclic… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Chronic obstructive pulmonary disease (COPD) is a common, progressive respiratory disease that causes great morbidity… Expand
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Highly Cited
2001
Highly Cited
2001
From a series of benzamide derivatives, roflumilast (3-cyclo-propylmethoxy-4-difluoromethoxy-N-[3,5-di-chloropyrid-4-yl… Expand
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Review
2001
Review
2001
  • M. Giembycz
  • Expert opinion on investigational drugs
  • 2001
  • Corpus ID: 21654297
Cilomilast (Ariflo™ , SB-207499) is an orally-active, second generation phosphodiesterase (PDE) inhibitor that may be effective… Expand
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