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Cilomilast

Known as: 4-cyano-4-(3-cyclopentoxy-4-methoxy-phenyl)-cyclohexane-1- carboxylic acid, Cilomilast [Chemical/Ingredient], Cis-4-Cyano-4-(3-(Cyclopentyloxy)-4-Methoxyphenyl)Cyclohexanecarboxylic Acid 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

ArifloSB 207499

Broader (3)

Cyclohexanecarboxylic AcidsNitrilesPhosphodiesterase 4 Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
The Efficacy and Safety of Cilomilast in COPD
The aim of this review is to present the clinical data on the efficacy and safety of cilomilast in patients with chronic… 
Highly Cited
2009
Highly Cited
2009
Discovery of selective PDE4B inhibitors.
Highly Cited
2008
Highly Cited
2008
PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways.
Highly Cited
2007
Highly Cited
2007
Roflumilast inhibits leukocyte‐endothelial cell interactions, expression of adhesion molecules and microvascular permeability
The present study addressed the effects of the investigational PDE4 inhibitor roflumilast on leukocyte‐endothelial cell… 
Highly Cited
2006
Highly Cited
2006
Cilomilast for COPD: Results of a 6-Month, Placebo-Controlled Study of a Potent, Selective Inhibitor of Phosphodiesterase 4
Background COPD is a relentless, progressive disease. This study evaluated the efficacy of cilomilast, a selective… 
Review
2005
Review
2005
PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression.
Highly Cited
2005
Highly Cited
2005
The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro.
Review
2004
Review
2004
PDE4 inhibition: a novel approach for the treatment of inflammatory bowel disease.
Review
2001
Review
2001
The next generation of PDE4 inhibitors.
Review
2001
Review
2001
Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease
Cilomilast (Ariflo™ , SB-207499) is an orally-active, second generation phosphodiesterase (PDE) inhibitor that may be effective… 
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