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Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands
An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands.
Linearized Reference Tissue Parametric Imaging Methods: Application to [11C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain
Rapid parametric imaging by MRTM2 should be a useful method for human [11C]DASB positron emission tomography studies as it allowed rapid generation of parametric images with the noise reductions consistent with the simulations.
MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.
A smaller right hippocampal volume in PTSD that is associated with functional deficits in verbal memory is consistent with high levels of cortisol associated with stress.
Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort.
In this new cohort of subjects the authors replicated their initial observation of a dysregulation of striatal dopamine release in schizophrenia, with a significantly larger reduction in D2 receptor availability following acute amphetamine challenge than the comparison group.
Strategies to Improve Neuroreceptor Parameter Estimation by Linear Regression Analysis
Three alternative linear methods to Logan graphical analysis are evaluated: GA using total least squares (TLS), and two multilinear analyses, MA1 and MA2, based on mathematical rearrangement of GA equation and two-tissue compartments, respectively, using simulated and actual PET data of two receptor tracers.
Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.
In the schizophrenic group, elevated amphetamine effect on [123I]IBZM binding potential was associated with emergence or worsening of positive psychotic symptoms, suggesting that psychotic symptoms elicited in this experimental setting in schizophrenia patients are associated with exaggerated stimulation of dopaminergic transmission.
Deficits in short-term memory in posttraumatic stress disorder.
Patients with PTSD may have deficits in short-term memory and Counseling and rehabilitation that address these deficits may be of value for PTSD patients.
In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease.
The results suggest that neuroinflammation, indicated by increased (11)C-PBR28 binding to TSPO, occurs after conversion of mild cognitive impairment to Alzheimer's disease and worsens with disease progression.
Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans