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Phenacetin

Known as: Phenacetin [Chemical/Ingredient], Acetphenetidin, 1-Acetamido-4-ethoxybenzene 
A synthetic, white crystalline solid that is slightly soluble in water and benzene, soluble in acetone and very soluble in pyrimidine. It is used in… 
National Institutes of Health

Related topics

Related topics

29 relations

Narrower (11)

3-hydroxyphenacetin phosphate4-nitrosophenetoleKeganminMidol

Broader (3)

Analgesics, Non-NarcoticGout Suppressantsacetamide
CYP1A2 protein, humanCytochrome P450 2D6, humanFeverIn Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression
Two cyclooxygenase isozymes, COX-1 and -2, are known to catalyze the rate-limiting step of prostaglandin synthesis and are the… 
Highly Cited
1999
Highly Cited
1999
The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds.
A post-column infusion system was developed in order to analyze suppression of electrospray ionization (ESI) tandem mass… 
Review
1997
Review
1997
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data.
Highly Cited
1995
Highly Cited
1995
Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s… 
Highly Cited
1993
Highly Cited
1993
Fluvoxamine is a potent inhibitor of cytochrome P4501A2.
Highly Cited
1990
Highly Cited
1990
Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.
Highly Cited
1989
Highly Cited
1989
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
Aromatic amines are well known as occupational carcinogens and are found in cooked foods, tobacco smoke, synthetic fuels, and… 
Highly Cited
1988
Highly Cited
1988
Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme.
Review
1980
Review
1980
Kinetics and metabolism of paracetamol and phenacetin.
1 The rate of absorption of oral paracetamol depends on the rate of gastric emptying and is usually rapid and complete. The mean… 
Highly Cited
1978
Highly Cited
1978
Central and peripheral antialgesic action of aspirin-like drugs.
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