• Publications
  • Influence
Kinetics and metabolism of paracetamol and phenacetin.
  • L. Prescott
  • Chemistry, Medicine
  • British journal of clinical pharmacology
  • 1 April 1980
TLDR
It is found that Phenacetin absorption depends on formulation, and it is extensively metabolized to paracetamol and minor metabolites are probably responsible for toxicity. Expand
Clinical Pharmacokinetics of Paracetamol
TLDR
In therapeutic doses paracetamol is a safe analgesic, but in overdosage it can cause severe hepatic necrosis and the plasma half-life is usually normal in patients with mild chronic liver disease, but is prolonged in those with decompensated liver disease. Expand
The dependence of paracetamol absorption on the rate of gastric emptying
TLDR
There was a significant correlation between the rate of gastric emptying and the 0·4 and 0·24 h urinary excretion of paracetamol and its metabolites, and individual differences in the rates may contribute to variable absorption of many drugs. Expand
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.
TLDR
Intravenous acetylcysteine was more effective than cysteamine and methionine and noticeably free of adverse effects and is the treatment of choice for paracetamol poisoning. Expand
Paracetamol: Past, Present, and Future
  • L. Prescott
  • Medicine
  • American journal of therapeutics
  • 1 March 2000
TLDR
Paracetamol is a first-line choice for pain management and antipyresis in a variety of patients, including children, pregnant women, the elderly, those with osteoarthritis, simple headaches, and those with noninflammatory musculoskeletal conditions. Expand
Paracetamol, alcohol and the liver.
  • L. Prescott
  • Chemistry, Medicine
  • British journal of clinical pharmacology
  • 1 April 2000
TLDR
Although the possibility remains that chronic consumption of alcohol does increase the risk of paracetamol hepatotoxicity in man (perhaps by impairing glutathione synthesis), there is insufficient evidence to support the alleged major toxic interaction. Expand
The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage
TLDR
The dosage schedule for intravenous N-acetylcysteine should probably be modified since adverse reactions invariably occur early when plasma concentrations are at their highest, and liver damage was prevented just as effectively at the lowest as at the highest Cmax. Expand
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.
TLDR
Intravenous acetylcysteine was more effective than cysteamine and methionine and noticeably free of adverse effects and is the treatment of choice for paracetamol poisoning. Expand
Kinetics of acetaminophen absorption and gastric emptying in man
TLDR
Pharmacokinetic analysis using a new model in which the conventional single compartment used to represent the gastrointestinal tract is replaced by two compartments showed good agreement in all cases, and provided an estimate of KA*, the first‐order rate constant for drug transfer from the intestinal lumen into the systemic circulation. Expand
Inter-subject and ethnic differences in paracetamol metabolism.
TLDR
The range of intersubject variation in the metabolic activation of paracetamol was sixty fold compared with only a three fold variation in glucuronide and sulphate conjugation, which has important implications for susceptibility to par acetamol hepatotoxicity following overdosage especially in a small subgroup showing extensive metabolic activation. Expand
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