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Pharmacological significance of the species differences in bupropion metabolism.
Bupropion provided a dose-dependent prevention of tetrabenazine-induced sedation in mice but not rats. Bupropion was extensively metabolized in mice, rats, dogs and man. About 85% of the dose wasExpand
Pharmacokinetics of mivacurium in normal patients and in those with hepatic or renal failure.
We have determined the pharmacokinetics and duration of action of a bolus dose of mivacurium (0.15 mg kg-1) during isoflurane and nitrous oxide anaesthesia in nine patients with normal renal andExpand
The in vitro degradation of cisatracurium, the R, cis‐R′‐isomer of atracurium, in human and rat plasma
To assess the mechanism and rate of in vitro degradation of cisatracurium in aqueous buffer and in human and rat plasma.
Estrogenic action of DDT and its analogs.
The intraperitoneal injection of 50 mg/kg of purified o,p′-DDT, technical grade DDT, purified methoxychlor, or purified p,p′-DDT increased the uterine wet weight by 49, 43, 37, and 28%, respectively,Expand
Effect of halogenated hydrocarbon insecticides on the metabolism and uterotropic action of estrogens in rats and mice.
Abstract Treatment of immature female rats with chlordane, dieldrin, heptachlor, lindane, p,p′ -DDD, p,p′ -DDE, or toxaphene for 7 days stimulated the metabolism of estrone by liver microsomalExpand
In Vitro Metabolism of Mivacurium Chloride (BW B1090U) and Succinylcholine
The in vitro rates of metabolism of mivacurium chloride and succinylcholine in pooled human plasma were compared. In addition, the rate of metabolism of mivacurium in buffered solutions ofExpand
Analgesie drugs in breast milk and plasma *
The disposition of salicylic acid, phenacetin, caffeine, and codeine, and two metabolites, acetaminophen and morphine, was studied in breast milk and plasma of two lactating mothers after single oralExpand
Comparative disposition of codeine and pholcodine in man after single oral doses.
Four healthy male subjects received single oral doses of 15, 30 and 60 mg of codeine and pholcodine according to a balanced cross-over design with an interval of 7 days between the six treatments.Expand
Cigarette Smoking: Stimulatory Effect on Metabolism of 3,4-Benzpyrene by Enzymes in Human Placenta
The enzymatic hydroxylation of 3,4-benzpyrene was not detected in human placentas obtained after childbirth from nonsmokers, whereas this enzyme activity was present in placentas obtained fromExpand
A simple method for the quantitative determination of N-acetyl-p-aminophenol (APAP) in urine.
A simple method is described for the rapid quantitative analysis of N-acetyl- p -amino-phenol (APAP) in urine. APAP and its conjugates present in the urine following the ingestion of acetophenetidin,Expand