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Pentazocine

Known as: Pentazocina, 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, (2alpha,6alpha,11R*)-, Pentazocine [Chemical/Ingredient] 
The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist… 
National Institutes of Health

Related topics

Related topics

34 relations
1 ML Pentazocine 30 MG/ML Injection [Talwin]Drug AllergyIn BloodIntracranial Hypertension

Broader (6)

Adjuvants, AnesthesiaAnalgesicsAnalgesics, OpioidNarcotic Antagonists

Narrower (8)

FortralJO 2871KF 1820Lexir

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Pursuit-related neurons in the supplementary eye fields: discharge during pursuit and passive whole body rotation.
The primate frontal cortex contains two areas related to smooth-pursuit: the frontal eye fields (FEFs) and supplementary eye… 
Highly Cited
2001
Highly Cited
2001
Development of a Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent.
Review
1990
Review
1990
Sigma binding sites in the brain; an emerging concept for multiple sites and their relevance for psychiatric disorders.
Review
1985
Review
1985
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats
Various pharmacokinetic parameters—disposition half-life, t1/2,z, metabolic clearance CLm, volume of distribution V, intrinsic… 
Highly Cited
1984
Highly Cited
1984
Post‐operative analgesia in the dog: a comparison of morphine, buprenorphine and pentazocine
The efficacy of buprenorphine and pentazocine in controlling pain in dogs following orthopaedic surgery was compared with that of… 
Highly Cited
1982
Highly Cited
1982
Potentiation of opioid analgesia by H1 and H2 antagonists.
Highly Cited
1975
Highly Cited
1975
Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster.
Highly Cited
1974
Highly Cited
1974
Pentazocine binding to blood cells and plasma proteins
The binding of pentazocine to human whole blood, plasma, and blood cells was investigated in 20 normal subjects and 22 patients… 
Highly Cited
1974
Highly Cited
1974
Effect of acutely administered analgesic drugs on rat brain serotonin turnover.
Highly Cited
1970
Highly Cited
1970
A method of identifying narcotic analgesics in human urine after therapeutic doses.
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