Pentazocine

Known as: Pentazocina, 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, (2alpha,6alpha,11R*)-, Pentazocine [Chemical/Ingredient] 
The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist… (More)
National Institutes of Health

Papers overview

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Review
2005
Review
2005
Toxicity resulting from excessive intra-synaptic serotonin, historically referred to as serotonin syndrome, is now understood to… (More)
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Highly Cited
2003
Highly Cited
2003
Sex specificity of neural mechanisms modulating nociceptive information has been demonstrated in rodents, and these qualitative… (More)
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Highly Cited
2003
Highly Cited
2003
The differential ability of various mu-opioid receptor (MOP) agonists to induce rapid receptor desensitization and endocytosis of… (More)
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Review
1999
Review
1999
Cigarette smoking remains highly prevalent in most countries. It can affect drug therapy by both pharmacokinetic and… (More)
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Review
1999
Review
1999
The liver is the major site of biotransformation for most opioids. Thus, the disposition of these drugs may be affected in… (More)
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Highly Cited
1999
Highly Cited
1999
Nalbuphine, pentazocine, and butorphanol, mixed agonist/antagonist opioids that induce analgesia by acting predominantly at kappa… (More)
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1997
1997
Sigma (sigma) receptors have generated a great deal of interest on the basis of their possible role in psychosis and on locomotor… (More)
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Highly Cited
1996
Highly Cited
1996
Sigma-ligands comprise several chemically unrelated drugs such as haloperidol, pentazocine, and ditolylguanidine, which bind to a… (More)
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Highly Cited
1996
Highly Cited
1996
Gender difference in analgesia produced by the kappa-opiate pentazocine was investigated in a model of post-operative dental pain… (More)
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1980
1980
Seventeen patients who had cutaneous complications following pentazocine injections are presented. The mean age was 50 years… (More)
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