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Pentazocine

Known as: Pentazocina, 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, (2alpha,6alpha,11R*)-, Pentazocine [Chemical/Ingredient] 
The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
  • P. Gillman
  • British journal of anaesthesia
  • 2005
  • Corpus ID: 6466937
Toxicity resulting from excessive intra-synaptic serotonin, historically referred to as serotonin syndrome, is now understood to… Expand
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Highly Cited
2003
Highly Cited
2003
Sex specificity of neural mechanisms modulating nociceptive information has been demonstrated in rodents, and these qualitative… Expand
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Review
1999
Review
1999
Cigarette smoking remains highly prevalent in most countries. It can affect drug therapy by both pharmacokinetic and… Expand
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Highly Cited
1998
Highly Cited
1998
Background:Since surgical trauma not only intensifies the oxidative stress by generating reactive oxygen species (ROS), but also… Expand
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Highly Cited
1997
Highly Cited
1997
Sigma (sigma) receptors have generated a great deal of interest on the basis of their possible role in psychosis and on locomotor… Expand
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Highly Cited
1996
Highly Cited
1996
Sigma-ligands comprise several chemically unrelated drugs such as haloperidol, pentazocine, and ditolylguanidine, which bind to a… Expand
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Highly Cited
1996
Highly Cited
1996
Gender difference in analgesia produced by the kappa-opiate pentazocine was investigated in a model of post-operative dental pain… Expand
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Highly Cited
1995
Highly Cited
1995
The ability of mu-opioid agonists to activate G proteins has been demonstrated by studying the binding of the GTP analogue… Expand
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Review
1984
Review
1984
SummaryFirst-pass elimination takes place when a drug is metabolised between its site of administration and the site of sampling… Expand
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Highly Cited
1978
Highly Cited
1978
Eight healthy male volunteers ingested an aqueous solution containing acetaminophen (20 mg/kg) and a nonabsorbable isotopic… Expand
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