Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats

Abstract

Various pharmacokinetic parameters—disposition half-life, t 1/2,z, metabolic clearance CLm, volume of distribution V, intrinsic clearance of unbound drug CLut, and unbound volume of distribution of tissues (distributive tissue volume / fraction of drug in tissue unbound, VT/fuT—are compared in rat and human for nine weakly acidic drugs, phenytoin… (More)
DOI: 10.1007/BF01059331

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