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Penicillamine

Known as: D Penicillamine, (S)-2-amino-3-mercapto-3-methylbutanoic acid, D-Valine, 3-mercapto- 
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and… 
National Institutes of Health

Related topics

Related topics

40 relations

Narrower (16)

6-aminopenicillanic acid gossypoloneAtamirCuprenilCuprimine
AgranulocytosisAntirheumatic AgentsBiliary cirrhosisChelating Activity [MoA]

Broader (2)

Amino Acids, SulfurChelating Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis: analysis of a two-year, double-blind, randomized, controlled clinical trial.
OBJECTIVE To test the hypothesis that systemic sclerosis (SSc) patients taking high-dose D-penicillamine (D-Pen) would have… 
Highly Cited
1994
Highly Cited
1994
Nitric oxide as a potential pathological mechanism in demyelination: Its differential effects on primary glial cellsin vitro
Review
1991
Review
1991
TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity.
Highly Cited
1989
Highly Cited
1989
Phosphatidylcholine hydrolysis by phospholipase D determines phosphatidate and diglyceride levels in chemotactic peptide-stimulated human neutrophils. Involvement of phosphatidate phosphohydrolase in…
Human neutrophils have been labeled in 1-O-alkyl-phosphatidylcholine (alkyl-PC) with 32P by incubation with alkyl-[32P]lysoPC… 
Highly Cited
1988
Highly Cited
1988
Tissue‐Type Plasminogen Activator Antigen and Plasminogen Activator Inhibitor in Diabetes Mellitus
Parameters of flbrlnolysls, Including euglobulln fibrlnolytlc activity, tissue-type plasminogen activator (t-PA) antigen… 
Highly Cited
1986
Highly Cited
1986
A role for oxygen free radicals in aminonucleoside nephrosis.
The cellular processes responsible for the proteinuria induced by the aminonucleoside of puromycin (PA) remain inadequately… 
Highly Cited
1984
Highly Cited
1984
Exercise‐induced arterial hypoxaemia in healthy human subjects at sea level.
We determined the incidence of exercise‐induced arterial hypoxaemia and its determinants in sixteen highly trained, healthy… 
Highly Cited
1980
Highly Cited
1980
Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols.
Review
1968
Review
1968
The use of chelating agents in the treatment of acute and chronic lead intoxication in childhood.
Highly Cited
1963
Highly Cited
1963
Some properties of L-glutamic decarboxylase in mouse brain.
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