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Penicillamine

Known as: D Penicillamine, (S)-2-amino-3-mercapto-3-methylbutanoic acid, D-Valine, 3-mercapto- 
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Metal ions accumulate in the brain with aging and in several neurodegenerative diseases. Aside from the copper storage disease… Expand
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Highly Cited
2001
Highly Cited
2001
Excessive nitric oxide (NO) production in cytokine-activated β cells has been implicated in β cell disruption in type 1 diabetes… Expand
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To study the clinical implications of a skin thickness score > or =20 at first visit and of softening of… Expand
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Highly Cited
1999
Highly Cited
1999
The reactivities of glutathione, cysteine, cysteamine, penicillamine, N-acetylcysteine, dithiothreitol and captopril with… Expand
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Highly Cited
1996
Highly Cited
1996
A subset of individuals with familial amyotrophic lateral sclerosis (FALS) possesses dominantly inherited mutations in the gene… Expand
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Highly Cited
1996
Highly Cited
1996
The free radicals nitric oxide and superoxide anion react to form peroxynitrite (ONOO-), a highly toxic oxidant species. In vivo… Expand
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Highly Cited
1995
Highly Cited
1995
Chondrocytes stimulated with IL-1 produce high levels of nitric oxide (NO), which inhibits proliferation induced by transforming… Expand
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Highly Cited
1984
Highly Cited
1984
We determined the incidence of exercise-induced arterial hypoxaemia and its determinants in sixteen highly trained, healthy… Expand
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Highly Cited
1983
Highly Cited
1983
The conformationally restricted, cyclic, disulfide-containing, enkephalin analogs [2-D-penicillamine, 5-L-penicillamine… Expand
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Highly Cited
1956
Highly Cited
1956
  • J. Walshe
  • The American journal of medicine
  • 1956
  • Corpus ID: 22441853
Abstract Of the compounds currently used in the treatment of Wilson's disease BAL appears to be the most generally useful… Expand
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