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Penicillamine

Known as: D Penicillamine, (S)-2-amino-3-mercapto-3-methylbutanoic acid, D-Valine, 3-mercapto- 
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and… 
National Institutes of Health

Related topics

Related topics

40 relations

Narrower (16)

6-aminopenicillanic acid gossypoloneAtamirCuprenilCuprimine
AgranulocytosisAntirheumatic AgentsBiliary cirrhosisChelating Activity [MoA]

Broader (2)

Amino Acids, SulfurChelating Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1997
1997
Direct Observation of Nitrosylated Heme in Myoglobin and Hemoglobin by Electrospray Ionization Mass Spectrometry
Using electrospray ionization mass spectrometry (ESI-MS), we demonstrate the direct observation of NO attached to the heme moiety… 
Highly Cited
1994
Highly Cited
1994
Comparative pharmacology of analogues of S‐nitroso‐N‐acetyl‐dl‐penicillamine on human platelets
1 The effects of two new analogues of S‐nitroso‐N‐acetyl‐dl‐penicillamine (SNAP), S‐nitroso‐N‐formyl‐dl‐penicillamine (SNFP) and… 
1993
1993
Therapeutic Effect of a Low Molecular Weight Dermatan Sulphate (Desmin 370) in Rat Venous Thrombosis - Evidence for an Anticoagulant-Independent Mechanism
Summary We evaluated the capacity of a low molecular weight dermatan sulphate (D370) to prevent thrombus formation and to induce… 
1989
1989
Induction of acantholysis in organ explant culture by penicillamine and captopril.
Pemphigus is an autoimmune disease proved to be mediated by IgG autoantibodies. Skin lesions clinically and histologically… 
Highly Cited
1977
Highly Cited
1977
Elastosis perforans serpiginosa induced by penicillamine.
A patient with Wilson disease, under prolonged treatment with penicillamine, developed lesions of elastosis perforans serpiginosa… 
1977
1977
Elastosis Perforans Serpiginosa Induced by Penicillamine: Electron Microscopic Observations
• A patient with Wilson disease, under prolonged treatment with penicillamine, developed lesions of elastosis perforans… 
Highly Cited
1974
Highly Cited
1974
N-Acetylprocainamide: An Active Metabolite of Procainamide 1
Summary N-Acetylprocainamide has been detected in the plasma samples of each of four patients receiving procainamide. The… 
Highly Cited
1970
Highly Cited
1970
Penicillamine-induced normalization of clinical signs, and liver morphology and histochemistry in a case of Wilson's disease.
After 27 months of daily penicillamine administration (250 mg 3 or 4 times daily) a portal cirrhosis in a 10-year-old girl was… 
1968
1968
Desmosine Biosynthesis: Nature of Inhibition by D-Penicillamine
Administration of D-penicillamine and lathyrogens such as β-amino-propionitrile to animals markedly alters connective tissue by… 
Highly Cited
1963
Highly Cited
1963
Treatment of Lead-poisoning with Oral Penicillamine
Sixteen sporadic cases in the general population and six cases in a small school outbreak of infections due to Eaton's primary… 
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