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Cellular pathophysiology of ischemic acute kidney injury.
The major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease are reviewed.
Acute kidney injury, mortality, length of stay, and costs in hospitalized patients.
- G. Chertow, E. Burdick, Melissa M. Honour, J. Bonventre, D. Bates
- MedicineJournal of the American Society of Nephrology…
- 1 November 2005
Modest changes in SCr were significantly associated with mortality, LOS, and costs, even after adjustment for age, gender, admission International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis, severity of illness (diagnosis-related group weight), and chronic kidney disease.
Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury.
- W. Han, V. Bailly, R. Abichandani, R. Thadhani, J. Bonventre
- Medicine, BiologyKidney international
- 1 July 2002
A soluble form of human KIM-1 can be detected in the urine of patients with ATN and may serve as a useful biomarker for renal proximal tubule injury facilitating the early diagnosis of the disease and serving as a diagnostic discriminator.
Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
- Li Yang, Tatiana Y. Besschetnova, C. Brooks, J. Shah, J. Bonventre
- Medicine, BiologyNature Medicine
- 1 May 2010
In ischemic, toxic and obstructive models of AKI, it is demonstrated that treatment with a JNK inhibitor, or bypassing the G2/M arrest by administration of a p53 inhibitor or the removal of the contralateral kidney, rescues fibrosis in the unilateral isChemic injured kidney.
Kidney Injury Molecule-1 (KIM-1), a Putative Epithelial Cell Adhesion Molecule Containing a Novel Immunoglobulin Domain, Is Up-regulated in Renal Cells after Injury*
Structurally and expression data suggest that KIM-1 is an epithelial cell adhesion molecule up-regulated in the cells, which are dedifferentiated and undergoing replication, and may play an important role in the restoration of the morphological integrity and function to postischemic kidney.
Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
Prostaglandin E2 levels in the cerebrospinal fluid are Elevated by finding a widespread induction of Cox-2 expression in spinal cord neurons and in other regions of the CNS, and preventing central prostanoid production by inhibiting the interleukin-1β-mediated induction ofcox-2 in neurons reduces centrally generated inflammatory pain hypersensitivity.
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis.
Data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease.
Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both…
- A. Abou-Samra, H. Jüppner, J. Potts
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 April 1992
Using expression cloning, a cDNA clone is isolated encoding rat bone PTH/PTHrP receptor from rat osteosarcoma cells that is 78% identical to the opossum kidney receptor and indicates striking conservation of this receptor across distant mammalian species.
Biomarkers of acute kidney injury.
- V. Vaidya, M. Ferguson, J. Bonventre
- Biology, MedicineAnnual review of pharmacology and toxicology
- 9 January 2008
Development of sensitive, specific, and reliable biomarkers for early diagnosis/prognosis of AKI in preclinical and clinical studies, and development and validation of high-throughput innovative technologies that allow rapid multiplexed detection of multiple markers at the bedside are greatly facilitated.
Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of…
- R. Witzgall, D. Brown, C. Schwarz, J. Bonventre
- BiologyThe Journal of clinical investigation
- 1 May 1994
The temporal and nephron segment expressions of various proteins implicated in mitogenesis, differentiation, and injury support the view that the mature renal S3 segment epithelial cell can be a progenitor cell.