A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron-microscopy
THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE
The early stages of absorption of intravenously injected horseradish peroxidase in proximal tubules of mouse kidney were studied with a new ultrastructural cytochemical technique, which gives sharp localization and is sensitive to protein transport.
A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES
219 Ins thue exheussivelv ussed Koelle ;onsd Fniederuwald histociueuusbcal nuetisod Ion cisolinsestersose, amid its several ns(odificat ions (see Pearse, Histocheun istry, 2moded., p. 478, Little,…
FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE
These findings localize, at a fine structural level, a "barrier" to the passage of peroxidase at the endothelium of vessels in the cerebral cortex in mice, particularly with reference to a recent study in which similar techniques were applied to capillaries in heart and skeletal muscle.
HEXAGONAL ARRAY OF SUBUNITS IN INTERCELLULAR JUNCTIONS OF THE MOUSE HEART AND LIVER
A new technique, based on the observations of Doggenweiler and Frenks, has allowed us to demonstrate the presence of similar structures in sections of mouse heart and of mouse liver.
THE ULTRASTRUCTURAL BASIS OF CAPILLARY PERMEABILITY STUDIED WITH PEROXIDASE AS A TRACER
- M. Karnovsky
- Biology, MedicineJournal of Cell Biology
- 1 October 1967
It is concluded that the endothelial cell junctions are most likely to be the morphological equivalent of the small pore system proposed by physiologists for the passage of small, lipid-insoluble molecules across the endothelium.
NONDROPLET ULTRASTRUCTURAL DEMONSTRATION OF CYTOCHROME OXIDASE ACTIVITY WITH A POLYMERIZING OSMIOPHILIC REAGENT, DIAMINOBENZIDINE (DAB)
- A. Seligman, M. Karnovsky, H. Wasserkrug, J. Hanker
- Biology, ChemistryJournal of Cell Biology
- 1 July 1968
The sites of reactivity of both parts of the respiratory chain have implications for the chemiosomotic hypothesis of Mitchell who suggests a mechanism of energy conservation during electron transport in the respiratory Chain of the mitochondrion.
THE LOCALIZATION OF CHOLINESTERASE ACTIVITY IN RAT CARDIAC MUSCLE BY ELECTRON MICROSCOPY
- M. Karnovsky
- BiologyJournal of Cell Biology
- 1 November 1964
It is proposed that the localization of cholinesterases in myocardium at the ultrastructural level should be taken into account in considering the possible functions of these myocardial enzymes, and it is hoped that knowledge of their localization will open up new avenues of approach in considering their physiological role inMyocardium.
Ultrastructural localization of several phosphatases with cerium.
Cerium appears to be a better capture agent for inorganic phosphate than lead in that reaction product is usually more uniform and more consistently reproducible when cerium is used.
Localization of NADH oxidase on the surface of human polymorphonuclear leukocytes by a new cytochemical method
These findings, combined with oxygen consumption studies on resting and stimulated PMN in the presence or absence of NADH, indicate that NADH oxidase is a surface enzyme in human PMN, which is internalized duringphagocytosis and retains its peroxide-generating capacity within the phagocytic vacuole.