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The occurrence of sleep-disordered breathing among middle-aged adults.
- T. Young, M. Palta, J. Dempsey, J. Skatrud, S. Weber, S. Badr
- The New England journal of medicine
- 29 April 1993
The prevalence of undiagnosed sleep-disordered breathing is high among men and is much higher than previously suspected among women, and is associated with daytime hypersomnolence. Expand
Pathophysiology of sleep apnea.
This work reviews three types of major long-term sequelae to severe OSA and discusses future research into understanding the pathophysiology of sleep apnea as a basis for uncovering newer forms of treatment of both the ventilatory disorder and its multiple sequelae. Expand
Longitudinal study of moderate weight change and sleep-disordered breathing.
The data indicate that clinical and public health programs that result in even modest weight control are likely to be effective in managing SDB and reducing new occurrence of SDB. Expand
Exercise-induced arterial hypoxemia.
It is suggested that mild EIAH be defined as an arterial O(2) saturation of 93-95% (or 3-4% 25-30 Torr) and inadequate compensatory hyperventilatory response, as do acid- and temperature-induced shifts in O( 2) dissociation at any given arterial PO(2). Expand
Respiratory muscle work compromises leg blood flow during maximal exercise.
It is concluded that Wb normally incurred during maximal exercise causes vasoconstriction in locomotor muscles and compromises locomotor muscle perfusion and VO2. Expand
Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance
It is suggested that feedback from fatiguing muscle plays an important role in the determination of central motor drive and force output, so that the development of peripheral muscle fatigue is confined to a certain level. Expand
Exercise‐induced arterial hypoxaemia in healthy human subjects at sea level.
It is suggested that hypoxaemia may be attributed to a diffusion limitation secondary to very short red cell transit times in at least a portion of the pulmonary circulation and non‐uniformity of the VA/QC distribution or veno‐arterial shunt could explain the hypoxAemia observed in most of the authors' subjects. Expand
Oxygen cost of exercise hyperpnea: implications for performance.
The O2 cost of exercise hyperpnea is a significant fraction of the total VO2max but is not sufficient to cause a critical level of "useful"hyperpnea to be achieved in healthy subjects. Expand
Exercise‐induced diaphragmatic fatigue in healthy humans.
It is concluded that significant diaphragmatic fatigue is caused by the ventilatory requirements imposed by heavy endurance exercise in healthy persons with a variety of fitness levels. Expand
Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise.
It is shown that the respiratory muscle work normally expended during maximal exercise has two significant effects on the cardiovascular system: up to 14-16% of the CO is directed to the respiratory muscles; and local reflex vasoconstriction significantly compromises blood flow to leg locomotor muscles. Expand