PTEN wt Allele

Known as: PTEN1, Phosphatase and Tensin Homolog, MHAM 
Human PTEN wild type allele is located in the vicinity of 10q23.3 and is approximately 109 kb in length. This allele, which encodes… (More)
National Institutes of Health

Related topics

Related topics

21 relations
10q23.31Bannayan-Riley-Ruvalcaba SyndromeCTCF PathwayEndometrial Endometrioid Adenocarcinoma
(More)

Broader (1)

PTEN gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
The CLIP-Domain Serine Protease Homolog SPCLIP1 Regulates Complement Recruitment to Microbial Surfaces in the Malaria Mosquito Anopheles gambiae
The complement C3-like protein TEP1 of the mosquito Anopheles gambiae is required for defense against malaria parasites and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2012
Highly Cited
2012
TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer
We integrated four gene expression profile data sets, namely two different pair-matched stage I lung adenocarcinoma data sets… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2006
Review
2006
GABA-A receptors: a viable target for novel anxiolytics?
Benzodiazepine (BZ) anxiolytics mediate their clinical effects by enhancing the effect of gamma-aminobutyric acid (GABA) at the… (More)
  • figure 1
  • figure 2
Is this relevant?
2002
2002
Intragenic PTEN/MMAC1 Loss of Heterozygosity in Conventional (Clear-Cell) Renal Cell Carcinoma is Associated with Poor Patient Prognosis
Inactivation of the PTEN/MMAC1 tumor suppressor gene has been linked to tumor progression in several human malignancies. However… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
Is this relevant?
Review
2000
Review
2000
The Multiple Roles of PTEN in Tumor Suppression
missense mutations in PTEN detected in primary tumors and in cell lines are confined to exon 5, which encodes this domain… (More)
  • figure 1
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype
Inhibitory neurotransmission in the brain is largely mediated by GABAA receptors. Potentiation of GABA receptor activation… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1999
1999
Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter.
Loss of heterozygosity on chromosome 10 (LOH#10) is the most frequent genetic alteration in glioblastomas and occurs in more than… (More)
Is this relevant?
1998
1998
PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate
Deletion of the q23-24 region of human chromosome 10 is one of the most frequent genetic alterations in prostate cancer… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
1997
Highly Cited
1997
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
A candidate tumor suppressor gene, MMAC1/PTEN, located in human chromosome band 10q23, was recently identified based on sequence… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
1997
Highly Cited
1997
PTEN1 is frequently mutated in primary endometrial carcinomas
 
Is this relevant?