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PTEN wt Allele

Known as: PTEN1, Phosphatase and Tensin Homolog, MHAM 
Human PTEN wild type allele is located in the vicinity of 10q23.3 and is approximately 109 kb in length. This allele, which encodes… 
National Institutes of Health

Related topics

Related topics

21 relations
10q23.31Bannayan-Riley-Ruvalcaba SyndromeCTCF PathwayEndometrial Endometrioid Adenocarcinoma
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Broader (1)

PTEN gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
GABA-A receptors: a viable target for novel anxiolytics?
  • P. Whiting
  • Current opinion in pharmacology
  • 2006
  • Corpus ID: 39422176
Benzodiazepine (BZ) anxiolytics mediate their clinical effects by enhancing the effect of gamma-aminobutyric acid (GABA) at the… 
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Review
2005
Review
2005
The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics
  • J. Atack
  • Expert opinion on investigational drugs
  • 2005
  • Corpus ID: 22793644
Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of… 
Review
2000
Review
2000
The Multiple Roles of PTEN in Tumor Suppression
Abstract In his celebrated monolog, the Shakespearean hero Hamlet clearly identified two extreme remedies: "To die: to sleep; no… 
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Highly Cited
2000
Highly Cited
2000
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype
Inhibitory neurotransmission in the brain is largely mediated by GABAA receptors. Potentiation of GABA receptor activation… 
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Review
2000
Review
2000
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.
Both inactivation of the tumor suppressor gene, PTEN/MMAC1, and oncogenic activation of RAS have been described in human… 
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Review
1999
Review
1999
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.
PTEN/MMAC1 (phosphatase, tensin homologue/mutated in multiple advanced cancers) is a tumor suppressor protein that has sequence… 
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Highly Cited
1998
Highly Cited
1998
PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate
Deletion of the q23-24 region of human chromosome 10 is one of the most frequent genetic alterations in prostate cancer… 
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Highly Cited
1997
Highly Cited
1997
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
A candidate tumor suppressor gene, MMAC1/PTEN, located in human chromosome band 10q23, was recently identified based on sequence… 
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Highly Cited
1997
Highly Cited
1997
PTEN1 is frequently mutated in primary endometrial carcinomas
Highly Cited
1978
Highly Cited
1978
Benzodiazepines: potentiation of a GABA inhibitory response in the dorsal raphe nucleus.
  • D. Gallager
  • European journal of pharmacology
  • 1978
  • Corpus ID: 35131783
Based on evidence that the dorsal raphe nucleus (DR) has specific and independent receptors for 5HT, GABA and glycine (Gallager… 
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