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PTEN wt Allele
Known as:
PTEN1
, Phosphatase and Tensin Homolog
, MHAM
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Human PTEN wild type allele is located in the vicinity of 10q23.3 and is approximately 109 kb in length. This allele, which encodes…
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National Institutes of Health
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Related topics
Related topics
21 relations
10q23.31
Bannayan-Riley-Ruvalcaba Syndrome
CTCF Pathway
Endometrial Endometrioid Adenocarcinoma
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Broader (1)
PTEN gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
The CLIP-Domain Serine Protease Homolog SPCLIP1 Regulates Complement Recruitment to Microbial Surfaces in the Malaria Mosquito Anopheles gambiae
M. Povelones
,
Lavanya Bhagavatula
,
+4 authors
G. Christophides
PLoS Pathogens
2013
Corpus ID: 1829213
The complement C3-like protein TEP1 of the mosquito Anopheles gambiae is required for defense against malaria parasites and…
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Review
2006
Review
2006
GABA-A receptors: a viable target for novel anxiolytics?
P. Whiting
Current opinion in pharmacology (Print)
2006
Corpus ID: 39422176
Review
2000
Review
2000
The Multiple Roles of PTEN in Tumor Suppression
A. Cristofano
,
P. Pandolfi
Cell
2000
Corpus ID: 5133017
Highly Cited
2000
Highly Cited
2000
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype
R. McKernan
,
T. Rosahl
,
+20 authors
P. Whiting
Nature Neuroscience
2000
Corpus ID: 10340592
Inhibitory neurotransmission in the brain is largely mediated by GABAA receptors. Potentiation of GABA receptor activation…
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Review
2000
Review
2000
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.
H. Tsao
,
X. Zhang
,
K. Fowlkes
,
F. Haluska
Cancer Research
2000
Corpus ID: 25251481
Both inactivation of the tumor suppressor gene, PTEN/MMAC1, and oncogenic activation of RAS have been described in human…
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Review
1999
Review
1999
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.
I. Ali
,
L. Schriml
,
M. Dean
Journal of the National Cancer Institute
1999
Corpus ID: 30332384
PTEN/MMAC1 (phosphatase, tensin homologue/mutated in multiple advanced cancers) is a tumor suppressor protein that has sequence…
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Highly Cited
1999
Highly Cited
1999
Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter.
H. Fujisawa
,
M. Kurrer
,
R. Reis
,
Y. Yonekawa
,
P. Kleihues
,
H. Ohgaki
American Journal of Pathology
1999
Corpus ID: 44553372
Highly Cited
1997
Highly Cited
1997
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
D. Teng
,
R. Hu
,
+22 authors
P. Steck
Cancer Research
1997
Corpus ID: 13409584
A candidate tumor suppressor gene, MMAC1/PTEN, located in human chromosome band 10q23, was recently identified based on sequence…
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Highly Cited
1997
Highly Cited
1997
PTEN1 is frequently mutated in primary endometrial carcinomas
D. Kong
,
A. Suzuki
,
+16 authors
A. Horii
Nature Genetics
1997
Corpus ID: 29666790
Highly Cited
1978
Highly Cited
1978
Benzodiazepines: potentiation of a GABA inhibitory response in the dorsal raphe nucleus.
D. Gallager
European Journal of Pharmacology
1978
Corpus ID: 35131783
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