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PTEN gene

Known as: PTEN, PTEN1, PHOSPHATASE AND TENSIN HOMOLOG DELETED ON CHROMOSOME 10 
This gene plays a role in signal transduction and apoptosis. It is also involved in the regulation of cell cycle progression.
National Institutes of Health

Related topics

Related topics

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Bannayan-Riley-Ruvalcaba SyndromeBartholin Gland Squamous Cell CarcinomaEndometrial Endometrioid AdenocarcinomaEndometrial Endometrioid Adenocarcinoma with a Poorly Differentiated Carcinomatous Component

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PTEN wt Allele

Papers overview

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2017
2017
Modulation of PI3K/PTEN Pathway Does Not Affect Catalytic Activity of PDK1 in Jurkat Cells.
Unopposed phosphoinositide 3-kinase (PI3K) activity and 3-phosphoinositide production in Jurkat cells, due to a mutation in the… 
2016
2016
MiR-23 a promotes cell proliferation and invasion in papillary thyroid carcinoma by targeting PTEN
Accumulating evidence has suggested that microRNAs (miRNAs) are involved in multiple processes in cancer development and… 
2015
2015
Association of the PTEN IVS 4 ( rs 3830675 ) Gene Polymorphism with Reduced Risk of Cancer : Evidence from a Meta-analysis
Cancer is a polygenic disease, which results from complex interactions between environmental and genetic factors (Pharoah et al… 
2011
2011
Abstract A52: PTEN/PTENP1 transcripts expression and alterations in a large panel of human tumor xenograft in nude mice: Implication for resistance to targeted therapies involving EGFR/PI3K/PTEN…
Background: PTEN alterations are major determinants of resistance to several new targeted therapies involving EGFR/PI3K/PTEN… 
2007
2007
Body Mass Index is Associated with Immunohistochemical Nuclear Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Expression in Stage IB-IC Endometrioid Endometrial Carcinoma*
Objective: To examine the relationship between clinicopathologic features and nuclear phosphatase and tensin homolog deleted on… 
2006
2006
Peroxisome Proliferator-Activated Receptor-and Retinoic Acid X Receptor Represses the TGF 1 Gene via PTEN-Mediated p 70 Ribosomal S 6 Kinase-1 Inhibition : Role for Zf 9 Dephosphorylation
Peroxisome proliferator-activated receptor (PPAR)and retinoic acid X receptor (RXR) heterodimer regulates cell growth and… 
2006
2006
p18 and Pten Constrain a Positive Regulatory Loop between Cell Growth and Cell Cycle Control
Inactivation of the Rb-mediated G 1 control pathway is a common event found in many types of human tumors. To test how the Rb… 
2004
2004
Advances in Brief PTEN UpRegulates the Tumor Metastasis Suppressor Gene Drg-1 in Prostate and Breast Cancer
PTEN (phosphatase and tensin homologue deleted on chromosome 10) has been shown to be inactivated in a wide variety of cancers… 
2003
2003
[Correlation between the PTEN/MMAC1/TEP1 expression and cell proliferation and apoptosis in human renal cell carcinoma (RCC)].
BACKGROUND & OBJECTIVE PTEN is a tumor suppressor gene with phosphatase activity. It had been proved the aberrant expression and… 
2000
2000
Overexpression of PTEN / MMAC 1 and Decreased Activation of Akt in Human Papillomavirus-infected Laryngeal Papillomas 1
Laryngeal papillomas are benign, human papillomavirus-induced hyperplastic tumors of the respiratory tract. They are…