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PTEN gene

Known as: PTEN, PTEN1, PHOSPHATASE AND TENSIN HOMOLOG DELETED ON CHROMOSOME 10 
This gene plays a role in signal transduction and apoptosis. It is also involved in the regulation of cell cycle progression.
National Institutes of Health

Related topics

Related topics

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Bannayan-Riley-Ruvalcaba SyndromeBartholin Gland Squamous Cell CarcinomaEndometrial Endometrioid AdenocarcinomaEndometrial Endometrioid Adenocarcinoma with a Poorly Differentiated Carcinomatous Component

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PTEN wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Knockdown of MicroRNA-122 Protects H9c2 Cardiomyocytes from Hypoxia-Induced Apoptosis and Promotes Autophagy
Background Acute myocardial infarction (AMI) is a severe disease causing heart failure and sudden death. Studies indicate that… 
Highly Cited
2007
Highly Cited
2007
The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death
Glioma tumor suppressor candidate region gene 2 (GLTSCR2/PICT-1) is localized within the well-known 1.4-Mb tumor suppressive… 
2007
2007
Mechanisms for the magnolol‐induced cell death of CGTH W‐2 thyroid carcinoma cells
Magnolol, a substance purified from the bark of Magnolia officialis, inhibits cell proliferation and induces apoptosis in a… 
Highly Cited
2005
Highly Cited
2005
Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a multifunctional tumor suppressor, has been shown to play a… 
Highly Cited
2001
Highly Cited
2001
Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
Molecular therapeutics, targeting the underlying defects leading to cancer initiation and progression, are the “holy grail” of… 
Highly Cited
2001
Highly Cited
2001
Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN.
The PTEN tumor suppressor gene encodes a multifunctional phosphatase that plays an important role in inhibiting the… 
2000
2000
Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene
High-frequent microsatellite instability (MSI-H) was detected in two of the 80 gliomas examined, whlie the other 78 gliomas… 
Review
1999
Review
1999
PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis.
The level of phosphorylation within cells is tightly regulated by the concerted action of protein kinases and protein… 
Highly Cited
1999
Highly Cited
1999
PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis
The tumor suppressor gene PTEN (MMAC1, TEP1) encodes a dual-specificity phosphatase and is considered a progression-associated… 
Highly Cited
1999
Highly Cited
1999
Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes.
Genetic alterations in the MMAC1 tumor suppressor gene (also referred to as PTEN or TEP1) occur in several types of human cancers… 
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