PTEN gene

Known as: PTEN, PTEN1, PHOSPHATASE AND TENSIN HOMOLOG DELETED ON CHROMOSOME 10 
This gene plays a role in signal transduction and apoptosis. It is also involved in the regulation of cell cycle progression.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
05019972017

Papers overview

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Highly Cited
2008
Highly Cited
2008
BACKGROUND There is much discussion in the cancer drug development community about how to incorporate molecular tools into early… (More)
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Highly Cited
2001
Highly Cited
2001
PTEN tumor suppressor is frequently mutated in human cancers and is a negative regulator of PI3'K/PKB/Akt-dependent cellular… (More)
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Highly Cited
1999
Highly Cited
1999
The PTEN/MMAC1/TEP (PTEN) tumor suppressor gene at 10q23.3 is mutated in multiple types of sporadic tumors including breast… (More)
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Highly Cited
1998
Highly Cited
1998
Since their discovery, protein tyrosine phosphatases have been speculated to play a role in tumor suppression because of their… (More)
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Highly Cited
1998
Highly Cited
1998
The long arm of chromosome 10 is frequently affected by allelic loss in prostate cancer. PTEN/MMAC1, a candidate tumor suppressor… (More)
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Highly Cited
1998
Highly Cited
1998
Cytogenetic and loss of heterozygosity studies have suggested the presence of at least one tumor suppressor gene on chromosome 10… (More)
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Highly Cited
1998
Highly Cited
1998
Mutated in multiple advanced cancers 1/phosphatase and tensin homologue (MMAC1/PTEN) is a novel tumor suppressor gene candidate… (More)
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Highly Cited
1997
Highly Cited
1997
Sporadic prostate carcinoma is the most common male cancer in the Western world, yet many of the major genetic events involved in… (More)
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Highly Cited
1997
Highly Cited
1997
Deletions involving regions of chromosome 10 occur in the vast majority (>90%) of human glioblastoma multiformes. A region at… (More)
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Highly Cited
1997
Highly Cited
1997
Endometrial carcinomas represent the most common gynecological cancer in the United States, yet the molecular genetic events that… (More)
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