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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHOExpand
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The 2007 WHO Classification of Tumours of the Central Nervous System
The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma,Expand
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Malignant astrocytic glioma: genetics, biology, and paths to treatment.
Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial tumors. These cancers exhibit a relentless malignant progression characterized by widespread invasionExpand
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The WHO Classification of Tumors of the Nervous System
The new World Health Organization (WHO) classification of nervous system tumors, published in 2000, emerged from a 1999 international consensus conference of neuropathologists. New entities includeExpand
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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
BACKGROUND The epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed, or mutated in glioblastomas, but only 10 to 20 percent of patients have a response to EGFR kinaseExpand
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Malignant glioma: genetics and biology of a grave matter.
Malignant brain tumors strike deep into the psyche of those receiving and those delivering the diagnosis. Malignant gliomas, the most common subtype of primary brain tumors, are aggressive, highlyExpand
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Pathology and genetics of tumours of the nervous system.
1: Astrocytic tumours Diffuse astrocytomas Low-grade diffuse astrocytomas Anaplastic astrocytoma Glioblastoma Giant cell glioblastoma Gliosarcoma Pilocytic astrocytoma Pleomorphic xanthoastrocytomaExpand
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WHO Classification of Tumours of the Central Nervous System. 4th Ed.
WHO Classification of Tumours of the Central Nervous System. 4th Ed. - Libros de Medicina - Oncologia general - 118,02
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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.
Although genetic analysis has demonstrated that members of the winged helix, or forkhead, family of transcription factors play pivotal roles in the regulation of cellular differentiation andExpand
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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.
The development and neoplastic progression of human astrocytic tumors appears to result through an accumulation of genetic alterations occurring in a relatively defined order. One such alteration isExpand
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