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TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer
This region contains a single confirmed gene, TSLC1, whose expression is reduced or absent in A549 and several other NSCLC, hepatocellular carcinoma (HCC) and pancreatic cancer (PaC) cell lines, and is correlated with promoter methylation state in these cell lines.
Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer.
Restoration of TSLC1 expression strongly suppressed the metastasis of a human non-small cell lung cancer cell line, A549, from the spleen to the liver in nude mice, suggesting that TS LC1 and DAL-1 play a critical role in the same pathway involved in the suppression of lung tumor formation and metastasis.
Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis
- Y. Murakami
- Biology, MedicineCancer science
- 1 September 2005
TSLC1/IGSF4 is ectopically expressed in adult T‐cell leukemia (ATL) cells, providing not only a diagnostic marker for ATL, but also a possible therapeutic target against its invasion.
Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma
The purpose of this study was to investigate the possible association of TSLC1/IGSF4 methylation with tobacco smoking as well as with the clinical characteristics of tumors using a large number of primary NSCLC.
Association between dense CADM1 promoter methylation and reduced protein expression in high‐grade CIN and cervical SCC
- R. Overmeer, FE Henken, +9 authors R. Steenbergen
- Biology, MedicineThe Journal of pathology
- 1 August 2008
The extent of CADM1 promoter methylation in cervical (pre)malignant lesions and its relation to anchorage‐independent growth and gene silencing is determined to select a CADM 1‐based methylation marker for identification of women at risk of cervical cancer.
Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines
- T. Fukami, H. Fukuhara, +5 authors Y. Murakami
- Biology, MedicineInternational journal of cancer
- 20 October 2003
Combined analysis of promoter methylation and the allelic state in these cell lines indicated that the TSLC1 gene was often silenced not only by mono‐allelic methylation associated with loss of the other allele but also through bi‐alleic methylation.
The Tumor Suppressor Protein TSLC1 Is Involved in Cell-Cell Adhesion*
- M. Masuda, M. Yageta, +4 authors Y. Murakami
- Biology, MedicineThe Journal of Biological Chemistry
- 23 August 2002
Results indicate that TSLC1 mediates intracellular adhesion through homophilic interactions in a Ca2+/Mg2+-independent manner.
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage
- A. Takeuchi, Mohamed Elsherif Gadelhaq Gadelhaq Badr, +11 authors Takashi Saito
- Biology, MedicineThe Journal of experimental medicine
- 11 January 2016
It is demonstrated that CRTAM identifies CD4 T cells with cytotoxic function, and new insights into CD4+CTL development are presented.
Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas.
The results suggest the involvement of at least two tumor suppressor genes in a late stage of hepatocarcinogenesis in primary hepatocellular carcinomas.
Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins
Two TSLC1-like genes, TSLL1 and TSLL2, are isolated based on their structural homology with the sequences corresponding to the cytoplasmic domain of TS LC1, indicating that these three genes form a unique subfamily (the TSLC 1-gene family) in the immunoglobulin superfamily genes.