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Validation of the ITS2 Region as a Novel DNA Barcode for Identifying Medicinal Plant Species
The second internal transcribed spacer (ITS2) of nuclear ribosomal DNA represents the most suitable region for DNA barcoding applications and can be potentially used as a standard DNA barcode to identify medicinal plants and their closely related species. Expand
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
The results suggest that MITA is a critical mediator of virus-triggered IRF3 activation and IFN expression and further demonstrate the importance of certain mitochondrial proteins in innate antiviral immunity. Expand
Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells.
The upper cervical corticospinal tract was transected on one side in adult rats. A suspension of ensheathing cells cultured from adult rat olfactory bulb was injected into the lesion site. ThisExpand
Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype
The results suggest that inactivating BAX mutations are selected for during the progression of colorectal MMP+ tumors and that the wild-type BAX gene plays a suppressor role in a p53-independent pathway for coloreCTal carcinogenesis. Expand
Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation
It is shown that the aryl hydrocarbon receptor (AhR) is a crucial regulator in maintaining IEL numbers in both the skin and the intestine, and that AhR deficiency or the lack of AhR ligands compromises the maintenance of IELs and the control of the microbial load and composition. Expand
Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats
It is shown that mats and wts function in a common pathway, and a human Mats ortholog (Mats1) can rescue the lethality associated with loss of Mats function in Drosophila. Expand
Regeneration of Adult Rat Corticospinal Axons Induced by Transplanted Olfactory Ensheathing Cells
The effect of the transplant was to form a “patch” of peripheral-type tissue across which the cut central axons regenerated and then continued to grow along their original central pathway. Expand
A viral phospholipase A2 is required for parvovirus infectivity.
Sequence analysis revealed phospholipase A2 (PLA2) motifs in capsid proteins of parvoviruses. Although PLA2 activity is not known to exist in viruses, putative PLA2s from divergent parvoviruses,Expand
Actin homolog MreBH governs cell morphogenesis by localization of the cell wall hydrolase LytE.
It is proposed that controlled elongation of rod-shaped B. subtilis depends on the coordination of cell wall synthesis and hydrolysis in helical tracts defined by MreB proteins, and that physical interactions with intracellular actin bundles can influence the later localization pattern of extracellular effectors. Expand
Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
A molecular mechanism involving protein deubiquitination that connects two important tumor suppressors, p53 and Beclin1, and a potent small molecule inhibitor of autophagy as a possible lead compound for developing anticancer drugs is provided. Expand