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Molecular cues to implantation.
It is hoped that the forthcoming information will generate new ideas and concepts for a process that is essential for maintaining procreation and solving major reproductive health issues in women. Expand
Roadmap to embryo implantation: clues from mouse models
A better understanding of periimplantation biology could alleviate female infertility and help to develop novel contraceptives and the future challenges of the field are highlighted. Expand
Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice
It is demonstrated herein that the targeted disruption of COX-2, but notCOX-1, in mice produces multiple failures in female reproductive processes that include ovulation, fertilization, implantation, and decidualization. Expand
Mechanisms of implantation: strategies for successful pregnancy
Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization. Expand
Preterm labor: One syndrome, many causes
The current understanding of the mechanisms of disease implicated in preterm labor are summarized and advances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tolerance are reviewed. Expand
Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors.
Clear evidence is presented that specific growth factors of embryonic and/or reproductive tract origin participate in preimplantation embryo development and blastocyst functions in an autocrine/paracrine manner. Expand
Current knowledge of the aetiology of human tubal ectopic pregnancy.
Current evidence supports the hypothesis that tubal ectopic pregnancy is caused by a combination of retention of the embryo within the Fallopian tube due to impaired embryo-tubal transport and alterations in the tubal environment allowing early implantation to occur. Expand
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.
It is demonstrated herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization, and several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARdelta, demonstrating the first reported biologic function of this receptor signaling pathway. Expand
Host cyclooxygenase-2 modulates carcinoma growth.
- C. Williams, M. Tsujii, J. Reese, S. Dey, R. DuBois
- Biology, Medicine
- The Journal of clinical investigation
- 1 June 2000
It was found that tumor growth was markedly attenuated inCOX-2(-/-), but not COX-1(-/-) or wild- type mice, and treatment of wild-type C57BL/6 mice bearing LLC tumors with a selective COX -2 inhibitor reduced tumor growth. Expand
Loss of cannabinoid receptor 1 accelerates intestinal tumor growth.
- D. Wang, Haibin Wang, W. Ning, M. Backlund, S. Dey, R. DuBois
- Biology, Medicine
- Cancer research
- 1 August 2008
The genetic and pharmacologic studies reveal that loss or inhibition of CB1 accelerated intestinal adenoma growth in Apc(Min/+) mice whereas activation ofCB1 attenuated intestinal tumor growth by inducing cell death via down-regulation of the antiapoptotic factor survivin. Expand