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Hypoinsulinemia Regulates Amphetamine-Induced Reverse Transport of Dopamine
TLDR
The present studies establish that PI3K signaling regulates the neurochemical actions of AMPH-like psychomotor stimulants and suggest that insulin signaling pathways may represent a novel mechanism for regulating DA transmission, one which may be targeted for the treatment of AM PH abuse and potentially other dopaminergic disorders. Expand
Behavioral analyses of GHB: receptor mechanisms.
TLDR
A better understanding of the similarities and differences between GHB and baclofen, as well as the pharmacological mechanisms of action underlying the recreational and therapeutic effects of GHB, could lead to more effective medications with fewer adverse effects. Expand
Effects of amphetamine and methylphenidate on delay discounting in rats: interactions with order of delay presentation
TLDR
The effects of amphetamine and methylphenidate under delay discounting procedures differed depending on the order of delay presentation, indicating that drug-induced changes in discounting were due, in part, to mechanisms other than altered sensitivity to reinforcer delay. Expand
Food deprivation increases oral and intravenous drug intake in rats.
TLDR
Results suggest that feeding condition may be a powerful determinant of drug-reinforced behavior. Expand
Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane in Rhesus Monkeys
TLDR
The data confirm in nonhuman primates a prominent role for 5-HT2A receptors in the discriminative stimulus effects of some drugs with hallucinogenic activity in humans, and indicates that different classes of hallucinogens exert qualitatively different discriminatives stimulus effects in nonhumans. Expand
Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine
TLDR
It is shown that [3H]DA uptake, measured in vitro and clearance of exogenously applied DA in’vivo, is significantly reduced in rats made hypoinsulinemic by a single injection of streptozotocin, providing exciting new evidence that actions of amphetamine on DA neurotransmission are insulin‐dependent. Expand
Comparison of noncontingent versus contingent cocaine administration on plasma corticosterone levels in rats.
TLDR
Results demonstrate that the active vs. passive administration of cocaine can differentially affect this neuroendocrine response, and plasma corticosterone levels were significantly higher in rat receiving contingent cocaine compared to those receiving noncontingent cocaine. Expand
Apparent pA2 analysis on the respiratory depressant effects of alfentanil, etonitazene, ethylketocyclazocine (EKC) and Mr2033 in rhesus monkeys.
TLDR
Results of the present study demonstrating homogeneous pA2 values for quadazocine with alfentanil, etonitazene, EKC and Mr2033 strongly suggest that the latter two compounds decrease respiratory function in rhesus monkeys by acting on mu receptors. Expand
Eating high-fat chow enhances sensitization to the effects of methamphetamine on locomotion in rats.
TLDR
While eating high-fat chow does not appear to alter sensitivity of rats to acutely-administered methamphetamine, it significantly increases the sensitization that develops to repeated intermittent administration of methamphetamine, suggesting that eating certain foods influences the development of sensitization to drugs acting on dopamine systems. Expand
The HIV Antiretroviral Drug Efavirenz has LSD-Like Properties
TLDR
Efavirenz’s prevailing behavioral effect in rodents is consistent with LSD-like activity mediated via the 5-HT2A receptor, and this finding correlates with the subjective experiences in humans who abuse efavirens and with specific dose-dependent adverse neuropsychiatric events, such as hallucinations and night terrors, reported by HIV patients taking it as a medication. Expand
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