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PML/RARA Fusion Protein

Known as: PML-RAR Protein, Inducer of Acute Promyelocytic Leukemia, PML-RARalpha Fusion Protein 
A fusion protein (797 aa, ~106 kDa) that is encoded by the PML/RARA fusion gene. This protein contains the B-box and the RING-finger domain from… 
National Institutes of Health

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4 relations
Fusion GenePML genePML/RARA Fusion Genearsenic trioxide

Papers overview

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Highly Cited
2006
Highly Cited
2006
Recruitment of the Histone Methyltransferase SUV39H1 and Its Role in the Oncogenic Properties of the Leukemia-Associated PML-Retinoic Acid Receptor Fusion Protein
ABSTRACT Leukemia-associated fusion proteins establish aberrant transcriptional programs, which result in the block of… 
Highly Cited
2003
Highly Cited
2003
Recruitment of Herpes Simplex Virus Type 1 Transcriptional Regulatory Protein ICP4 into Foci Juxtaposed to ND10 in Live, Infected Cells
ABSTRACT At the early stages of herpes simplex virus type 1 (HSV-1) infection, parental viral genomes have a tendency to become… 
Highly Cited
2003
Highly Cited
2003
Neutrophil Elastase Cleaves PML-RARα and Is Important for the Development of Acute Promyelocytic Leukemia in Mice
Highly Cited
2003
Highly Cited
2003
PML Residue Lysine 160 Is Required for the Degradation of PML Induced by Herpes Simplex Virus Type 1 Regulatory Protein ICP0
ABSTRACT During the early stages of herpes simplex virus type 1 (HSV-1) infection, viral immediate-early regulatory protein ICP0… 
Highly Cited
2002
Highly Cited
2002
Cancer Epigenetics and Methylation
An important question in the field of cancer epigenetics involves the causes of CpG island hypermethylation in tumor suppressor… 
Review
1997
Review
1997
Acute promyelocytic leukemia: biology and treatment.
The discovery of the specific PML-RAR alpha gene rearrangement in acute promyelocytic leukemia (APL) and of the in vitro and in… 
Highly Cited
1996
Highly Cited
1996
Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein.
Promyelocytic leukemia zinc finger-retinoic acid receptor a (PLZF-RARalpha), a fusion receptor generated as a result of a variant… 
Highly Cited
1995
Highly Cited
1995
Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix- associated PML bodies
The PML protein was first identified as part of a fusion product with the retinoic acid receptor alpha (RAR alpha), resulting… 
Highly Cited
1995
Highly Cited
1995
The PML gene encodes a phosphoprotein associated with the nuclear matrix.
The t(15;17)(q22;q12) translocation is the cytogenetic hallmark of acute promyelocytic leukemia (APL). The PML and retinoic acid… 
Highly Cited
1992
Highly Cited
1992
Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.
Two chimeric genes, PML-RAR alpha and RAR alpha-PML, are formed as a consequence of the acute promyelocytic leukemia (APL… 
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