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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
TLDR
Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype, NPM gene mutations, and responsiveness to induction chemotherapy.
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
TLDR
Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
The p66shc adaptor protein controls oxidative stress response and life span in mammals
TLDR
It is proposed that p66shc is part of a signal transduction pathway that regulates stress apoptotic responses and life span in mammals.
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
TLDR
It is shown that senescence, triggered by the expression of an activated oncogene (H-RasV12) in normal human cells, is a consequence of the activation of a robust DDR, and proposed that OIS results from the enforcement of a DDR triggered by oncogen-induced DNA hyper-replication.
The tripartite motif family identifies cell compartments
TLDR
The results demonstrate that TRIM proteins share a common function: by means of homo‐multimerization they identify specific cell compartments.
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
TLDR
Investigating aspects of HDACi action both in vitro and in vivo will further improve the design of optimized clinical protocols and help to understand the role of histone deacetylases in tumorigenesis.
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
TLDR
It is found that oncogenic Ras upregulates PML expression, and overexpression of PML induces senescence in a p53-dependent manner, and integrity of the PML bodies is required for p53 acetylation and senescences upon oncogene expression.
Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?
TLDR
It is proposed that genes that control H2O2 production are selected determinants of lifespan and not simply the result of a genetic programme or the by-product of physiological processes.
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