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PML/RARA Fusion Gene

Known as: PML-RAR, PML-RAR Alpha Fusion Gene, PML-RARA Fusion Gene 
A fusion gene that results from a chromosomal translocation t(15;17)(q22;q21) which fuses the first 3 exons of the PML gene with the last 7 exons of… 
National Institutes of Health

Related topics

Related topics

8 relations
Acute Promyelocytic LeukemiaMicrogranular Acute Promyelocytic LeukemiaPML genePML/RARA Fusion Protein

Papers overview

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Highly Cited
2008
Highly Cited
2008
Murine Gammaherpesvirus 68 Open Reading Frame 75c Tegument Protein Induces the Degradation of PML and Is Essential for Production of Infectious Virus
ABSTRACT Promyelocytic Leukemia nuclear body (PML NB) proteins mediate an intrinsic cellular host defense response against virus… 
2008
2008
KIT and FLT3 receptor tyrosine kinase mutations in acute myeloid leukemia with favorable cytogenetics: two novel mutations and selective occurrence in leukemia subtypes and age groups.
Highly Cited
2006
Highly Cited
2006
Recruitment of the Histone Methyltransferase SUV39H1 and Its Role in the Oncogenic Properties of the Leukemia-Associated PML-Retinoic Acid Receptor Fusion Protein
ABSTRACT Leukemia-associated fusion proteins establish aberrant transcriptional programs, which result in the block of… 
Review
2001
Review
2001
Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?
Recent discoveries have identified key molecular events in the pathogenesis of acute promyelocytic leukemia (APL), caused by… 
Review
2001
Review
2001
ATRA(ouble) in the treatment of acute promyelocytic leukemia.
Acute promyelocytic leukemia (APL) is a unique disease that responds to differentiation-inducing effects of all-trans-retinoic… 
Review
1999
Review
1999
The molecular biology of acute promyelocytic leukemia.
The preceding two years have witnessed an explosion in the accumulation of knowledge relating to the molecular pathogenesis of… 
Highly Cited
1995
Highly Cited
1995
Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways.
The t(15;17) chromosomal translocation, specific for acute promyelocytic leukemia (APL), fuses the PML gene to the retinoic acid… 
Highly Cited
1993
Highly Cited
1993
The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1.
We report here that the fusion of PML, a nuclear protein defined by the t(15;17) chromosomal translocation in acute promyelocytic… 
Highly Cited
1992
Highly Cited
1992
Occurrence of distinct PML-RAR-alpha fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction.
A specific 'nested' reverse transcriptase/polymerase chain reaction (RT/PCR) procedure was used to characterize the expression… 
Highly Cited
1992
Highly Cited
1992
Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation.
The acute promyelocytic leukemia 15;17 chromosomal translocation fuses the PML gene to the RAR alpha locus. The resulting… 
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