Acute Promyelocytic Leukemia

Known as: Leukemia, Progranulocytic, AML M3, LEUKEMIA, PROMYELOCYTIC 
An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. It is characterized by the t(15;17)(q22;q12) translocation. There are… (More)
National Institutes of Health

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Broader (2)

Leukemia, Myelocytic, Acuteleukemia

Papers overview

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Highly Cited
2013
Highly Cited
2013
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia.
BACKGROUND All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL… (More)
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Review
2001
Review
2001
All trans retinoic acid in acute promyelocytic leukemia.
All trans retinoic acid (ATRA) is able to induce complete remission (CR) in almost all patients with acute promyelocytic leukemia… (More)
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Highly Cited
1998
Highly Cited
1998
Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide.
BACKGROUND Two reports from China have suggested that arsenic trioxide can induce complete remissions in patients with acute… (More)
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Highly Cited
1997
Highly Cited
1997
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients.
The therapeutic effect of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) was evaluated among 15… (More)
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Highly Cited
1997
Highly Cited
1997
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.
The malignant cells of acute promyelocytic leukemia (APL) contain a reciprocal chromosomal translocation that fuses the… (More)
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Review
1993
Review
1993
Acute promyelocytic leukemia.
Perhaps the most important advance in this field is not the specific actions of all-trans-retinoic acid in acute promyelocytic… (More)
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Highly Cited
1991
Highly Cited
1991
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML
A unique mRNA produced in leukemic cells from a t(15;17) acute promyelocytic leukemia (APL) patient encodes a fusion protein… (More)
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Highly Cited
1991
Highly Cited
1991
NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3).
Acute promyelocytic leukemia (APL) is a well-defined entity among acute leukemia, cytogenetically characterized by a t(15;17… (More)
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Highly Cited
1990
Highly Cited
1990
All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results.
Twenty-two patients with acute promyelocytic leukemia were treated with all-trans retinoic acid (RA, 45 mg/m2 per day) for 90… (More)
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Highly Cited
1989
Highly Cited
1989
Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia.
Twenty-four patients with acute promyelocytic leukemia (API) were treated with all-trans retinoic acid (45 to 100 mg/m2/day). Of… (More)
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