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Acute Promyelocytic Leukemia
Known as:
Leukemia, Progranulocytic
, AML M3
, LEUKEMIA, PROMYELOCYTIC
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An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. It is characterized by the t(15;17)(q22;q12) translocation. There are…
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National Institutes of Health
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Related topics
Related topics
47 relations
Arsenic
Bone Marrow
Bone Marrow Stem Cell with Potential to Differentiate to Granulocytic Lineage
Bone marrow stem cell
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Broader (2)
Leukemia, Myelocytic, Acute
leukemia
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Acute promyelocytic leukemia: from highly fatal to highly curable.
Zhen-yi Wang
,
Zhu Chen
Blood
2008
Corpus ID: 16707972
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia. Morphologically, it is identified as the M3…
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Highly Cited
1999
Highly Cited
1999
Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
A. Melnick
,
J. Licht
1999
Corpus ID: 11355474
I N THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute promyelocytic leukemia (APL) emerged as a…
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Highly Cited
1998
Highly Cited
1998
Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide.
S. Soignet
,
P. Maslak
,
+9 authors
R. Warrell
New England Journal of Medicine
1998
Corpus ID: 760664
BACKGROUND Two reports from China have suggested that arsenic trioxide can induce complete remissions in patients with acute…
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Highly Cited
1997
Highly Cited
1997
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
M. Jang
,
Lining Cai
,
+9 authors
J. Pezzuto
Science
1997
Corpus ID: 30850300
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive…
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Highly Cited
1997
Highly Cited
1997
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients.
Z. Shen
,
G. Chen
,
+17 authors
Z. Wang
Blood
1997
Corpus ID: 28880779
The therapeutic effect of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) was evaluated among 15…
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Highly Cited
1991
Highly Cited
1991
Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid).
R. Warrell
,
S. Frankel
,
+7 authors
A. Jakubowski
New England Journal of Medicine
1991
Corpus ID: 43841610
BACKGROUND AND METHODS Patients with acute promyelocytic leukemia have a characteristic (15;17) translocation, with a breakpoint…
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Highly Cited
1990
Highly Cited
1990
All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results.
S. Castaigne
,
C. Chomienne
,
+4 authors
L. Degos
Blood
1990
Corpus ID: 37406785
Twenty-two patients with acute promyelocytic leukemia were treated with all-trans retinoic acid (RA, 45 mg/m2 per day) for 90…
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Highly Cited
1988
Highly Cited
1988
Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia.
M. Huang
,
Y. Ye
,
+5 authors
Z. Wang
Haematology and blood transfusion
1988
Corpus ID: 1438123
Twenty-four patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (45 to 100 mg/m2/day). Of…
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Review
1987
Review
1987
The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.
S. Collins
Blood
1987
Corpus ID: 19024156
The HL-60 cell line, derived from a single patient with acute promyelocytic leukemia, provides a unique in vitro model system for…
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Highly Cited
1978
Highly Cited
1978
Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.
S. Collins
,
F. Ruscetti
,
R. Gallagher
,
R. Gallo
Proceedings of the National Academy of Sciences…
1978
Corpus ID: 37753585
A human leukemic cell line (designated HL-60) has recently been established from the peripheral blood leukocytes of a patient…
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