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Acute Promyelocytic Leukemia

Known as: Leukemia, Progranulocytic, AML M3, LEUKEMIA, PROMYELOCYTIC 
An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. It is characterized by the t(15;17)(q22;q12) translocation. There are… 
National Institutes of Health

Related topics

Related topics

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ArsenicBone MarrowBone Marrow Stem Cell with Potential to Differentiate to Granulocytic LineageBone marrow stem cell

Broader (2)

Leukemia, Myelocytic, Acuteleukemia

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Acute promyelocytic leukemia with, t( 15; 17) abnormality after, chemotherapy containing etoposide for, Langerhans cell histiocytosis
of their disease. Obviously, a randomized double-blind study is a much better design to assess drug efficacy. However, we… 
Review
2003
Review
2003
Retinoid target genes in acute promyelocytic leukemia
All-trans-retinoic acid (RA)-based differentiation therapy induces clinical remissions in acute promyelocytic leukemia (APL… 
Review
2002
Review
2002
Abnormalities in hemostasis in acute promyelocytic leukemia
Our understanding of the hemostatic abnormalities in acute promyelocytic leukemia (APL) has undergone remarkable changes over the… 
Highly Cited
1997
Highly Cited
1997
Differentiation therapy for acute promyelocytic leukemia.
Until recently, chemotherapy and hematopoietic stem-cell transplantation were the only therapeutic options in acute leukemia. The… 
Highly Cited
1996
Highly Cited
1996
Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase.
All-trans retinoic acid (t-RA) administration leads to complete remission in acute promyelocytic leukemia (APL) patients by… 
Highly Cited
1995
Highly Cited
1995
Accumulation of human promyelocytic leukemic (HL-60) cells at two energetic cell cycle checkpoints.
Agents that disrupt mitochondrial function were used to monitor the contribution of ATP to cell cycle progression. Following… 
Highly Cited
1992
Highly Cited
1992
A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia.
The t(15;17) translocation is specifically observed in patients with promyelocytic leukemia (AML3). The chromosomal rearrangement… 
Highly Cited
1985
Highly Cited
1985
Retinoic acid-induced expression of tissue transglutaminase in human promyelocytic leukemia (HL-60) cells.
Highly Cited
1981
Highly Cited
1981
Terminal differentiation surface antigens of myelomonocytic cells are expressed in human promyelocytic leukemia cells (HL60) treated with chemical inducers.
The expression of two surface antigens present on the cell membrane of both human granulocytes and monocytes was studied during… 
Highly Cited
1979
Highly Cited
1979
Chromosome abnormalities in acute promyelocytic leukemia (APL)
Sixteen patients, 15 adults and one child, with APL have been studied cytogenetically; 14 of these had an abnormal karyotype (87… 
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