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Acute Promyelocytic Leukemia

Known as: Leukemia, Progranulocytic, AML M3, LEUKEMIA, PROMYELOCYTIC 
An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. It is characterized by the t(15;17)(q22;q12) translocation. There are… Expand
National Institutes of Health

Related topics

Related topics

47 relations
ArsenicBone MarrowBone Marrow Stem Cell with Potential to Differentiate to Granulocytic LineageBone marrow stem cell
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Broader (2)

Leukemia, Myelocytic, Acuteleukemia

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
EULAR recommendations for the management of antiphospholipid syndrome in adults
The objective was to develop evidence-based recommendations for the management of antiphospholipid syndrome (APS) in adults… Expand
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Review
2019
Review
2019
Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet.
Since the comprehensive recommendations for the management of acute promyelocytic leukemia (APL) reported in 2009, several… Expand
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Highly Cited
1999
Highly Cited
1999
Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
I N THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute promyelocytic leukemia (APL) emerged as a… Expand
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Highly Cited
1998
Highly Cited
1998
Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide.
BACKGROUND Two reports from China have suggested that arsenic trioxide can induce complete remissions in patients with acute… Expand
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Highly Cited
1997
Highly Cited
1997
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive… Expand
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Highly Cited
1997
Highly Cited
1997
All-trans-retinoic acid in acute promyelocytic leukemia.
BACKGROUND All-trans-retinoic acid induces complete remission in acute promyelocytic leukemia. However, it is not clear whether… Expand
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Highly Cited
1997
Highly Cited
1997
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients.
The therapeutic effect of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) was evaluated among 15… Expand
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Highly Cited
1991
Highly Cited
1991
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML
A unique mRNA produced in leukemic cells from a t(15;17) acute promyelocytic leukemia (APL) patient encodes a fusion protein… Expand
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Highly Cited
1991
Highly Cited
1991
The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
We have previously shown that the t(15;17) translocation specifically associated with acute promyelocytic leukemia (APL) fuses… Expand
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Highly Cited
1989
Highly Cited
1989
Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia.
Acute promyelocytic leukemia (APL) is considered to be a distinct entity among the acute myeloid leukemias (AMLs). Hemorrhagic… Expand
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