PLP1 gene

Known as: Proteolipid Protein 1 (Pelizaeus-Merzbacher Disease, Spastic Paraplegia 2, Uncomplicated) Gene, DM20, PROTEOLIPID PROTEIN, MYELIN 
This gene is involved in neuronal development.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2018
010203019702018

Papers overview

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Highly Cited
2007
Highly Cited
2007
The prevailing mechanism for recurrent and some nonrecurrent rearrangements causing genomic disorders is nonallelic homologous… (More)
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Highly Cited
2002
Highly Cited
2002
Myelination, the process by which glial cells ensheath and electrically insulate axons, has been investigated intensely… (More)
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Highly Cited
2002
Highly Cited
2002
In the majority of patients with Pelizaeus-Merzbacher disease, duplication of the proteolipid protein gene PLP1 is responsible… (More)
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Highly Cited
2000
Highly Cited
2000
Intrathymic expression of tissue-specific self antigens may be involved in immunological tolerance and protection from autoimmune… (More)
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Highly Cited
1998
Highly Cited
1998
Pelizaeus-Merzbacher disease (PMD) is a dysmyelinating disease resulting from mutations, deletions, or duplications of the… (More)
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Highly Cited
1996
Highly Cited
1996
We have established a new permanent cell line (OLN-93), derived from spontaneously transformed cells in primary rat brain glial… (More)
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Highly Cited
1994
Highly Cited
1994
Three forms of X–linked spastic paraplegia (SPG) have been defined. One locus (SPG 1) maps to Xq28 while two clinically distinct… (More)
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Highly Cited
1994
Highly Cited
1994
Myelin proteolipid protein (PLP), the major myelin protein in the CNS, has been thought to function in myelin assembly. Thus… (More)
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Highly Cited
1994
Highly Cited
1994
Proteolipid protein (PLP) is an integral membrane protein of CNS myelin. Mutations of the X chromosome-linked PLP gene cause… (More)
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Highly Cited
1989
Highly Cited
1989
PLP is the major protein constituent of central nervous system myelin. We have previously shown that SJL/J (H-2s) mice develop an… (More)
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