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Axonal swellings and degeneration in mice lacking the major proteolipid of myelin.
TLDR
Fiber degeneration could indicate that myelinated axons require local oligodendroglial support, and two myelin membrane proteolipids, PLP and DM20, were shown to be essential for the integrity of myelination.
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
TLDR
Systemic administration of [Ser(2)]exendin(1–9) in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons and represents a promising new target for both cognitive-enhancing and neuroprotective agents.
Mitochondrial CB1 receptors regulate neuronal energy metabolism
TLDR
It is shown that the type-1 cannabinoid receptor (CB1) is present at the membranes of mouse neuronal mitochondria, where it directly controls cellular respiration and energy production, revealing a new mechanism of action of G protein–coupled receptor signaling in the brain.
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
Neuronal activity provokes myelinating oligodendrocytes to release exosomes by stimulation of ionotropic glutamate receptors, and that once released, these vesicles are internalized by neurons
Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation.
TLDR
Length-dependent axonal degeneration without demyelination was identified in the CNS of Plp1 null mice, and this degeneration is length-dependent, similar to that found in the PNS of patients with the inherited Demyelinating neuropathy, CMT1A, but is not associated with significant demYelination.
Extinction Training after Cocaine Self-Administration Induces Glutamatergic Plasticity to Inhibit Cocaine Seeking
TLDR
Data identify a cellular mechanism that may contribute to extinction-induced inhibition of cocaine seeking by extinction training and indicate that the elevation in Homer1b/c in the core may have sequestered mGluR5 away from the membrane surface and that the loss of surface mGLUR5 inhibits long-term depression.
Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
TLDR
The role of T-cell tolerance to proteolipid protein (PLP) in susceptibility to experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, is analyzed and lack of tolerance to this epitope offers an explanation for the exquisite susceptibility of SJL/J mice to EAE.
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