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Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma
- J. Baron, J. Madri, N. Ruddle, G. Hashim, C. Janeway
- Biology, MedicineThe Journal of experimental medicine
- 1 January 1993
It is concluded that surface expression of alpha 4 integrin is important in CD4 T cell entry into brain parenchyma and may be crucial in allowing activated effector T cells to leave blood and enter the brain and other tissues to clear infections.
Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis
This is the first report demonstrating the use of a synthetic T CR V-region peptide to induce specific regulatory immunity and has important implications for the regulation of human disease characterized by common TCR V-gene usage.
Delineation and synthesis of the membrane receptor-binding domain of sex hormone-binding globulin.
Two separate 18-amino acid domains of tau promote the polymerization of tubulin.
Response of human T lymphocyte lines to myelin basic protein: Association of dominant epitopes with HLA class II restriction molecules
- Y. Chou, M. Vainiene, +5 authors A. Vandenbark
- Biology, MedicineJournal of neuroscience research
- 1 June 1989
Data provide the first evidence of genetically restricted human T cell recognition of potentially encephalitogenic epitopes of MBP, and HLA‐DR2, which is overrepresented in MS patients, possessed an unusual capacity to restrict all eight epitopes identified on MBP in this study.
Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis.
The predominance of a PLP immune response rather than a BP response in SJL/J mice suggests that genetic background may determine the predominant myelin Ag response in human demyelinating diseases such as multiple sclerosis.
Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice.
The identification of a PLP peptide that is encephalitogenic in PL/J mice, in addition to the previous demonstration ofPLP peptides that are encephal itogenic for SWR mice and SJL/j mice, lends support to a role for PLP as a target Ag in autoimmune demyelinating diseases.
Basic A1 protein of the myelin membrane. The complete amino acid sequence.
- E. Eylar, S. Brostoff, G. Hashim, J. Caccam, P. Burnett
- Chemistry, MedicineThe Journal of biological chemistry
- 25 September 1971
The over-all sequence reveals no obvious periodicity but rather a general distribution of basic residues over the polypeptide chain, making the interaction with phospholipids within the myelin matrix highly probable.
Myelin Basic Protein: Structure, Function and Antigenic Determinants
- G. Hashim
- Biology, MedicineImmunological reviews
- 1 June 1978