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Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma
It is concluded that surface expression of alpha 4 integrin is important in CD4 T cell entry into brain parenchyma and may be crucial in allowing activated effector T cells to leave blood and enter the brain and other tissues to clear infections.
Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis
This is the first report demonstrating the use of a synthetic T CR V-region peptide to induce specific regulatory immunity and has important implications for the regulation of human disease characterized by common TCR V-gene usage.
Response of human T lymphocyte lines to myelin basic protein: Association of dominant epitopes with HLA class II restriction molecules
Data provide the first evidence of genetically restricted human T cell recognition of potentially encephalitogenic epitopes of MBP, and HLA‐DR2, which is overrepresented in MS patients, possessed an unusual capacity to restrict all eight epitopes identified on MBP in this study.
Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis.
The predominance of a PLP immune response rather than a BP response in SJL/J mice suggests that genetic background may determine the predominant myelin Ag response in human demyelinating diseases such as multiple sclerosis.
Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice.
The identification of a PLP peptide that is encephalitogenic in PL/J mice, in addition to the previous demonstration ofPLP peptides that are encephal itogenic for SWR mice and SJL/j mice, lends support to a role for PLP as a target Ag in autoimmune demyelinating diseases.
Basic A1 protein of the myelin membrane. The complete amino acid sequence.
The over-all sequence reveals no obvious periodicity but rather a general distribution of basic residues over the polypeptide chain, making the interaction with phospholipids within the myelin matrix highly probable.
Myelin Basic Protein: Structure, Function and Antigenic Determinants
  • G. Hashim
  • Biology, Medicine
    Immunological reviews
  • 1 June 1978