Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma
- J. Baron, J. Madri, N. Ruddle, G. Hashim, C. Janeway
- Biology, MedicineJournal of Experimental Medicine
- 1 January 1993
It is concluded that surface expression of alpha 4 integrin is important in CD4 T cell entry into brain parenchyma and may be crucial in allowing activated effector T cells to leave blood and enter the brain and other tissues to clear infections.
Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis
This is the first report demonstrating the use of a synthetic T CR V-region peptide to induce specific regulatory immunity and has important implications for the regulation of human disease characterized by common TCR V-gene usage.
Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice.
The identification of a PLP peptide that is encephalitogenic in PL/J mice, in addition to the previous demonstration ofPLP peptides that are encephal itogenic for SWR mice and SJL/j mice, lends support to a role for PLP as a target Ag in autoimmune demyelinating diseases.
Basic A1 protein of the myelin membrane. The complete amino acid sequence.
- E. Eylar, S. Brostoff, G. Hashim, J. Caccam, P. Burnett
- Chemistry, BiologyJournal of Biological Chemistry
- 25 September 1971
The over-all sequence reveals no obvious periodicity but rather a general distribution of basic residues over the polypeptide chain, making the interaction with phospholipids within the myelin matrix highly probable.
Treatment of multiple sclerosis with T–cell receptor peptides: Results of a double–blind pilot trial
A T–cell receptor (TCR) peptide vaccine from the Vβ5.2 sequence expressed in multiple sclerosis plaques and on myelin basic protein (MBP)–specific T cells boosted peptide–reactive T cells in patients with progressive MS, implicating a bystander suppression mechanism that holds promise for treatment of MS and other autoimmune diseases.
Two separate 18-amino acid domains of tau promote the polymerization of tubulin.
Delineation and synthesis of the membrane receptor-binding domain of sex hormone-binding globulin.
Myelin Basic Protein: Structure, Function and Antigenic Determinants
- G. Hashim
- MedicineImmunological Reviews
- 1 June 1978
Response of human T lymphocyte lines to myelin basic protein: Association of dominant epitopes with HLA class II restriction molecules
Data provide the first evidence of genetically restricted human T cell recognition of potentially encephalitogenic epitopes of MBP, and HLA‐DR2, which is overrepresented in MS patients, possessed an unusual capacity to restrict all eight epitopes identified on MBP in this study.
Myelin basic protein–specific T lymphocytes in multiple sclerosis and controls: Precursor frequency, fine specificity, and cytotoxicity
- Z. Jingwu, R. Medaer, G. Hashim, Y. Chin, E. M. van den Berg-Loonen, J. Raus
- Biology, MedicineAnnals of Neurology
- 1 September 1992
The majority of T‐cell lines (>75%) were found to exhibit substantial cytotoxic activity against MBP‐coated target cells, but showing no significant difference between these two groups, andMBP‐dependent Cytotoxicity was not associated with epitope specificities of the T‐ cell lines tested.