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PLAT protein, human

Known as: receptor, tissue plasminogen activator, human, Tissue-Type Plasminogen Activator, TTPA receptor, human 
An enzyme made in the body that helps dissolve blood clots. A form of this enzyme is made in the laboratory to treat heart attacks, strokes, and… 
National Institutes of Health

Related topics

Related topics

18 relations
AE-941Blood coagulationEGF-Like DomainEndothelial Cells

Broader (1)

alteplase

Papers overview

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Highly Cited
2003
Highly Cited
2003
Intra-Arterial Tumor Necrosis Factor-&agr; Impairs Endothelium-Dependent Vasodilatation and Stimulates Local Tissue Plasminogen Activator Release in Humans
Objective—Inflammation contributes to the pathogenesis of cardiovascular disease, potentially through the actions of… 
Highly Cited
1998
Highly Cited
1998
Real-time imaging of the axonal transport of granules containing a tissue plasminogen activator/green fluorescent protein hybrid.
A hybrid protein, tPA/GFP, consisting of rat tissue plasminogen activator (tPA) and green fluorescent protein (GFP) was expressed… 
Highly Cited
1991
Highly Cited
1991
Characterization of the tryptic map of recombinant DNA derived tissue plasminogen activator by high-performance liquid chromatography-electrospray ionization mass spectrometry.
A detailed tryptic map is presented for recombinant human tissue plasminogen activator (rt-PA). Electrospray ionization mass… 
Highly Cited
1989
Highly Cited
1989
Recurrent ischemia without warning. Analysis of risk factors for in-hospital ischemic events following successful thrombolysis with intravenous tissue plasminogen activator.
Ischemic events after successful thrombolysis have been reported to occur in 18-32% of patients treated for acute myocardial… 
Highly Cited
1988
Highly Cited
1988
Fatal ischaemic brain oedema after early thrombolysis with tissue plasminogen activator in acute stroke.
Two patients with acute major, disabling cerebral infarction with presumed middle cerebral artery occlusion were treated with the… 
Highly Cited
1988
Highly Cited
1988
Tissue-type plasminogen activator binding to human endothelial cells. Evidence for two distinct binding sites.
Highly Cited
1987
Highly Cited
1987
The Thrombolysis in Myocardial Infarction (TIMI) phase II pilot study: tissue plasminogen activator followed by percutaneous transluminal coronary angioplasty.
Highly Cited
1986
Highly Cited
1986
Determination of tissue plasminogen activator and its "fast" inhibitor in plasma.
We describe efficient, accurate methods for specific determination of tissue plasminogen activator (t-PA, EC 3.4.21.31) and its… 
Highly Cited
1982
Highly Cited
1982
Enzymatic properties of the one- and two-chain form of tissue plasminogen activator.
Highly Cited
1972
Highly Cited
1972
Differences in the Binding to Fibrin of Urokinase and Tissue Plasminogen Activator
Summary When present during clot formation, tissue plasminogen activator (TA, porcine) is strongly bound to fibrin, in marked… 
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