alteplase

Known as: T-Plasminogen Activator, Tissue Activator D 44, TPA 
A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test… (More)
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Review
2014
Review
2014
BACKGROUND Alteplase is effective for treatment of acute ischaemic stroke but debate continues about its use after longer times… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Intravenous alteplase is approved for use within 3 h of ischaemic stroke onset, although a meta-analysis of randomised… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The aim of the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST) was to assess the safety and… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The use of thrombolytic agents in the treatment of hemodynamically stable patients with acute submassive pulmonary… (More)
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Highly Cited
1999
Highly Cited
1999
C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of interleukin-6, predicts coronary… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Thrombolysis for acute ischaemic stroke has been investigated in several clinical trials, with variable results. We… (More)
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