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alteplase

Known as: T-Plasminogen Activator, Tissue Activator D 44, TPA 
A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (19)

ActilyseActivaseD-K2PFb-Fb-CF
Drug AllergyIn BloodIncreased Thrombolysis [PE]Intracranial Embolism and Thrombosis

Broader (1)

Fibrinolytic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Aspiration Thrombectomy After Intravenous Alteplase Versus Intravenous Alteplase Alone
Background and Purpose— Thrombectomy, primarily with stent retrievers with or without adjunctive aspiration, provided clinical… 
Highly Cited
2004
Highly Cited
2004
Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes
Identifying regions of the human genome that have been targets of natural selection will provide important insights into human… 
Highly Cited
1997
Highly Cited
1997
Hemorrhagic transformation in acute ischemic stroke. Potential contributing factors in the European Cooperative Acute Stroke Study.
BACKGROUND AND PURPOSE Recent studies suggest that thrombolytic therapy may be of benefit to patients with acute ischemic stroke… 
Highly Cited
1989
Highly Cited
1989
Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cells.
Wall shear stress generated by blood flow may regulate the expression of fibrinolytic proteins by endothelial cells. Tissue… 
Highly Cited
1988
Highly Cited
1988
Thrombolysis in myocardial infarction (TIMI) trial: Phase I. A comparison between intravenous tissue plasminogen activator and intravenous streptokinase
Highly Cited
1988
Highly Cited
1988
Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).
Highly Cited
1987
Highly Cited
1987
Thrombolysis inMyocardial Infarction (TIMI) Trial, Phase I:acomparison between intravenous tissue plasminogen activator andintravenous streptokinase*
Intravenous administration of80mg ofrecombinant tissue plasminogen activator (rt- PA,40,20,and20mg insuccessive hours… 
Highly Cited
1985
Highly Cited
1985
Production of abnormal proteins in E. coli stimulates transcription of ion and other heat shock genes
Highly Cited
1974
Highly Cited
1974
SECRETION OF PLASMINOGEN ACTIVATOR BY STIMULATED MACROPHAGES
Cultured thioglycollate-stimulated peritoneal macrophages synthesize, accumulate, and continuously release high levels of… 
Highly Cited
1959
Highly Cited
1959
The mechanism of clot dissolution by plasmin.
Normal human and animal sera contain a glob-ulin, plasminogen, which in the presence of acti-vators is rapidly converted to… 
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