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Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial.
Human genetic variation and its contribution to complex traits
Most common SNPs have now been assessed in genome-wide studies for statistical associations with many complex traits, including many important common diseases, and only a limited amount of the heritable component of any complex trait has been identified.
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events.
Overall, clopidogrel plus aspirin was not significantly more effective than aspirin alone in reducing the rate of myocardial infarction, stroke, or death from cardiovascular causes.
Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and prevention.
A multifaceted strategy aimed at prevention of vein graft disease is emerging, elements of which include: continued improvements in surgical technique; more effective antiplatelet drugs; increasingly intensive risk factor modification; and a number of evolving therapies, such as gene transfer and nitric oxide donor administration, which target vein graft Disease at an early and fundamental level.
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
High-performance medicine: the convergence of human and artificial intelligence
- E. Topol
- Medicine, Computer ScienceNature Medicine
- 1 January 2019
Over time, marked improvements in accuracy, productivity, and workflow will likely be actualized, but whether that will be used to improve the patient–doctor relationship or facilitate its erosion remains to be seen.
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
It is concluded that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial.
Bivalirudin with provisional Gp IIb/IIIa blockade is statistically not inferior to heparin plus planned Gp IIIa blockade during contemporary PCI with regard to suppression of acute ischemic end points and is associated with less bleeding.
Prevalence of conventional risk factors in patients with coronary heart disease.
A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease.