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Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial.
Following PCI, long-term clopidogrel therapy significantly reduced the risk of adverse ischemic events and subgroup analyses suggest that longer intervals between the loading dose and PCI may reduce events. Expand
Human genetic variation and its contribution to complex traits
Most common SNPs have now been assessed in genome-wide studies for statistical associations with many complex traits, including many important common diseases, and only a limited amount of the heritable component of any complex trait has been identified. Expand
Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and prevention.
A multifaceted strategy aimed at prevention of vein graft disease is emerging, elements of which include: continued improvements in surgical technique; more effective antiplatelet drugs; increasingly intensive risk factor modification; and a number of evolving therapies, such as gene transfer and nitric oxide donor administration, which target vein graft Disease at an early and fundamental level. Expand
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
It is shown that Stromal-cell-derived factor 1 (SDF-1) is sufficient to induce therapeutic stem-cell homing to injured myocardium and suggested a strategy for directed stem- cell engraftment into injured tissues. Expand
Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial.
Bivalirudin with provisional Gp IIb/IIIa blockade is statistically not inferior to heparin plus planned Gp IIIa blockade during contemporary PCI with regard to suppression of acute ischemic end points and is associated with less bleeding. Expand
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
It is concluded that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall. Expand
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events.
- Deepak L. Bhatt, K. Fox, +23 authors E. Topol
- The New England journal of medicine
- 20 April 2006
Overall, clopidogrel plus aspirin was not significantly more effective than aspirin alone in reducing the rate of myocardial infarction, stroke, or death from cardiovascular causes. Expand
A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease.
- P. Gum, K. Kottke-Marchant, P. Welsh, Jennifer A. White, E. Topol
- Journal of the American College of Cardiology
- 19 March 2003
This study demonstrates the natural history of aspirin resistance in a stable population, documenting a greater than threefold increase in the risk of major adverse events associated with aspirin resistance. Expand
Protein carbamylation links inflammation, smoking, uremia and atherogenesis
The discovery of an alternative and quantitatively dominant mechanism for cyanate formation and protein carbamylation at sites of inflammation and atherosclerotic plaque is reported: myeloperoxidase-catalyzed oxidation of thiocyanate, an anion abundant in blood whose levels are elevated in smokers. Expand
High-performance medicine: the convergence of human and artificial intelligence
- E. Topol
- Computer Science, Medicine
- Nature Medicine
- 1 January 2019
Over time, marked improvements in accuracy, productivity, and workflow will likely be actualized, but whether that will be used to improve the patient–doctor relationship or facilitate its erosion remains to be seen. Expand