PIK3C3 gene

Known as: phosphatidylinositol 3-kinase catalytic subunit type 3, VPS34, YEAST, HOMOLOG OF, PHOSPHATIDYLINOSITOL 3-KINASE, CLASS 3 
This gene plays a role in autophagosome formation and transport to lysosomes and late endosomes.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Autophagy is a cellular defense response to stress conditions, such as nutrient starvation. The type III phosphatidylinositol… (More)
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Highly Cited
2011
Highly Cited
2011
Autophagy normally involves the formation of double-membrane autophagosomes that mediate bulk cytoplasmic and organelle… (More)
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Highly Cited
2010
Highly Cited
2010
The lipid kinase PIK3C3 (also called Vps34) regulates both the endosomal and autophagic pathways. However, the effect of… (More)
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Highly Cited
2010
Highly Cited
2010
Phosphoinositide 3-kinases (PI3Ks) are lipid kinases with diverse roles in health and disease. The primordial PI3K, Vps34, is… (More)
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Highly Cited
2008
Highly Cited
2008
Salmonella colonizes a vacuolar niche in host cells during infection. Maturation of the Salmonella-containing vacuole (SCV… (More)
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Highly Cited
1995
Highly Cited
1995
A membrane-associated complex composed of the Vps15 protein kinase and the Vps34 phosphatidylinositol 3-kinase (PtdIns 3-kinase… (More)
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Highly Cited
1994
Highly Cited
1994
The cDNA encoding phosphatidylinositol (PI) 3-kinase was cloned from Arabidopsis thaliana, and the derived amino acid sequence… (More)
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Highly Cited
1993
Highly Cited
1993
The VPS34 gene product (Vps34p) is required for protein sorting to the lysosome-like vacuole of the yeast Saccharomyces… (More)
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Highly Cited
1993
Highly Cited
1993
The Vps15 protein kinase and the Vps34 phosphatidylinositol 3-kinase (PI 3-kinase) are required for the sorting of soluble… (More)
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Highly Cited
1993
Highly Cited
1993
Rapamycin is a macrolide antifungal agent that exhibits potent immunosuppressive properties. In Saccharomyces cerevisiae… (More)
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