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- Publications
- Influence
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- D. Klionsky, Kotb Abdelmohsen, +2,464 authors S. Zughaier
- Biology, Medicine
- Autophagy
- 18 April 2012
In 2008 we published the first set of guidelines for
standardizing research in autophagy. Since then, research on
this topic has continued to accelerate, and many new scientists
have entered the… Expand
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
- F. Ikeda, Yonathan Lissanu Deribe, +17 authors I. Dikic
- Biology, Medicine
- Nature
- 31 March 2011
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system disorders and multi-organ inflammation. Here we report that SHARPIN… Expand
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
- R. Iozzo, L. Schaefer
- Biology, Medicine
- Matrix biology : journal of the International…
- 18 February 2015
We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location,… Expand
Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns*
- L. Schaefer
- Biology, Medicine
- The Journal of Biological Chemistry
- 12 November 2014
In reply to internal or external danger stimuli, the body orchestrates an inflammatory response. The endogenous triggers of this process are the damage-associated molecular patterns (DAMPs). DAMPs… Expand
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis.
- M. Königshoff, M. Kramer, +9 authors O. Eickelberg
- Biology, Medicine
- The Journal of clinical investigation
- 1 April 2009
Idiopathic pulmonary fibrosis (IPF) is characterized by distorted lung architecture and loss of respiratory function. Enhanced (myo)fibroblast activation, ECM deposition, and alveolar epithelial type… Expand
Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction*
- L. Schaefer, R. Iozzo
- Biology, Chemistry
- Journal of Biological Chemistry
- 1 August 2008
The small leucine-rich proteoglycan (SLRP) family has significantly expanded in the past decade to now encompass five discrete classes, grouped by common structural and functional properties. Some of… Expand
Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine‐rich proteoglycans
- R. Iozzo, L. Schaefer
- Biology, Medicine
- The FEBS journal
- 1 October 2010
The small leucine‐rich proteoglycans (SLRPs) are involved in many aspects of mammalian biology, both in health and disease. They are now being recognized as key signaling molecules with an expanding… Expand
Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4.
- R. Allam, C. R. Scherbaum, +17 authors H. Anders
- Biology, Medicine
- Journal of the American Society of Nephrology…
- 7 June 2012
In AKI, dying renal cells release intracellular molecules that stimulate immune cells to secrete proinflammatory cytokines, which trigger leukocyte recruitment and renal inflammation. Whether the… Expand
Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis.
- H.-J. Anders, L. Schaefer
- Biology, Medicine
- Journal of the American Society of Nephrology…
- 1 July 2014
Tissue injury initiates an inflammatory response through the actions of immunostimulatory molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs encompass a group of… Expand
Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors*
- A. Bábelová, Kristin Moreth, +8 authors L. Schaefer
- Biology, Medicine
- The Journal of Biological Chemistry
- 15 July 2009
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need double stimulation with ligands to both… Expand